caa a22 4500 378921878 CHVBK 20180305123607.0 cr unu---uuuuu 161128e20040101xx s 000 0 eng 10.1351/pac200476071295 doi (NATIONALLICENCE)gruyter-10.1351/pac200476071295 Development of acid-sensitive copolymer micelles for drug delivery [Elektronische Daten] [E. R. Gillies, J. M. J. Fréchet] In recent years, supramolecular micellar assemblies formed from amphiphilic block copolymers have been receiving attention as potential drug carriers. The size of the carriers is ideal for avoiding rapid renal exclusion and reticuloendothelial uptake, and enables them to be targeted to certain tissues such as tumors. One important issue determining the effectiveness of a micellar drug carrier is the ability to control the time over which drug release takes place, or to possibly trigger drug release at a specific location or time. The mildly acidic pH encountered in tumor and inflammatory tissues as well as in the endosomal and lysosomal compartments of cells has inspired the development of micellar carriers capable of releasing their drug load in response to small changes in pH. One approach to the development of these systems has been to incorporate "titratable” groups such as amines and carboxylic acids into the copolymer backbone, thus altering the solubility of the polymer upon protonation and disrupting micelle formation. Another approach has been to incorporate acid-degradable linkages into the copolymer, either for direct attachment of the drug, or to cause a structural change of such magnitude that micellar integrity is lost and the drug is released. © 2013 Walter de Gruyter GmbH, Berlin/Boston Gillies E. R. Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, CA 94720, USA aut Fréchet J. M. J. Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, CA 94720, USA aut Pure and Applied Chemistry De Gruyter 76/7-8(2004-01-01), 1295-1307 0033-4545 76:7-8<1295 2004 76 pac https://doi.org/10.1351/pac200476071295 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1351/pac200476071295 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gillies E. R. Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, CA 94720, USA aut NATIONALLICENCE 700 1- Fréchet J. M. J. Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, CA 94720, USA aut NATIONALLICENCE 773 0- Pure and Applied Chemistry De Gruyter 76/7-8(2004-01-01), 1295-1307 0033-4545 76:7-8<1295 2004 76 pac CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter