Concerns About Unreliable Data from Spotted cDNA Microarrays Due to Cross-Hybridization and Sequence Errors

Verfasser / Beitragende:
[Daniel Handley, Nicoleta Serban, David G Peters, Clark Glymour]
Ort, Verlag, Jahr:
2004
Enthalten in:
Statistical Applications in Genetics and Molecular Biology, 3/1(2004-10-06), 1-2
Format:
Artikel (online)
ID: 378925768
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024 7 0 |a 10.2202/1544-6115.1091  |2 doi 
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245 0 0 |a Concerns About Unreliable Data from Spotted cDNA Microarrays Due to Cross-Hybridization and Sequence Errors  |h [Elektronische Daten]  |c [Daniel Handley, Nicoleta Serban, David G Peters, Clark Glymour] 
520 3 |a We discuss our concerns regarding the reliability of data generated by spotted cDNA microarrays. Two types of error we highlight are cross-hybridization artifact due to sequence homologies and sequence errors in the cDNA used for spotting on microarrays. We feel that statisticians who analyze microarray data should be aware of these sources of unreliability intrinsic to cDNA microarray design and use. 
540 |a ©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston 
690 7 |a Microarrays  |2 nationallicence 
690 7 |a Cross-hybridization  |2 nationallicence 
690 7 |a Sequence Errors  |2 nationallicence 
690 7 |a cDNA microarray  |2 nationallicence 
690 7 |a Sources of Error  |2 nationallicence 
700 1 |a Handley  |D Daniel  |u University of Pittsburgh  |4 aut 
700 1 |a Serban  |D Nicoleta  |u Carnegie Mellon University  |4 aut 
700 1 |a Peters  |D David G.  |u University of Pittsburgh  |4 aut 
700 1 |a Glymour  |D Clark  |u Carnegie Mellon University  |4 aut 
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