A Family-Based Association Test for Repeatedly Measured Quantitative Traits Adjusting for Unknown Environmental and/or Polygenic Effects
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| 024 | 7 | 0 | |a 10.2202/1544-6115.1067 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.2202/1544-6115.1067 | ||
| 245 | 0 | 2 | |a A Family-Based Association Test for Repeatedly Measured Quantitative Traits Adjusting for Unknown Environmental and/or Polygenic Effects |h [Elektronische Daten] |c [Christoph Lange, Kristel van Steen, Toby Andrew, Helen Lyon, Dawn L DeMeo, Benjamin Raby, Amy Murphy, Edwin K Silverman, Alex MacGregor, Scott T Weiss, Nan M Laird] |
| 520 | 3 | |a We propose a family-based association test, FBAT-PC, for studies with quantitative traits that are measured repeatedly. The traits may be influenced by partially or completely unknown factors that may vary for each measurement. Using generalized principal component analysis, FBAT-PC amplifies the genetic effects of each measurement by constructing an overall phenotype with maximal heritability. Analytically, and in the simulation studies, we compare FBAT-PC with standard methodology and assess both the heritability of the overall phenotype and the power of FBAT-PC. Compared to univariate analysis, FBAT-PC achieves power gains of up to 200%. Applications of FBAT-PC to an osteoporosis study and to an asthma study show the practical relevance of FBAT-PC. FBAT-PC has been implemented in the software package PBAT and is freely available at http://www.biostat.harvard.edu/~clange/default.htm. | |
| 540 | |a ©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston | ||
| 690 | 7 | |a Longitudinal Data Analysis and Time Series |2 nationallicence | |
| 690 | 7 | |a Genetics |2 nationallicence | |
| 690 | 7 | |a Multivariate Analysis |2 nationallicence | |
| 690 | 7 | |a family-based association test |2 nationallicence | |
| 690 | 7 | |a unknown environmental and/or polygenic effects |2 nationallicence | |
| 700 | 1 | |a Lange |D Christoph |u Harvard School of Public Health |4 aut | |
| 700 | 1 | |a van Steen |D Kristel |u Harvard School of Public Health |4 aut | |
| 700 | 1 | |a Andrew |D Toby |u St Thomas' Hospital, London SE1 7EH, UK |4 aut | |
| 700 | 1 | |a Lyon |D Helen |u Harvard Medical School |4 aut | |
| 700 | 1 | |a DeMeo |D Dawn L. |u Brigham and Women |4 aut | |
| 700 | 1 | |a Raby |D Benjamin |u Harvard Medical School |4 aut | |
| 700 | 1 | |a Murphy |D Amy |u Harvard School of Public Health |4 aut | |
| 700 | 1 | |a Silverman |D Edwin K. |u Brigham and Women |4 aut | |
| 700 | 1 | |a MacGregor |D Alex |u St Thomas' Hospital, London |4 aut | |
| 700 | 1 | |a Weiss |D Scott T. |u Harvard Medical School |4 aut | |
| 700 | 1 | |a Laird |D Nan M. |u Harvard School of Public Health |4 aut | |
| 773 | 0 | |t Statistical Applications in Genetics and Molecular Biology |d De Gruyter |g 3/1(2004-08-12), 1-27 |q 3:1<1 |1 2004 |2 3 |o sagmb | |
| 856 | 4 | 0 | |u https://doi.org/10.2202/1544-6115.1067 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.2202/1544-6115.1067 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lange |D Christoph |u Harvard School of Public Health |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a van Steen |D Kristel |u Harvard School of Public Health |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Andrew |D Toby |u St Thomas' Hospital, London SE1 7EH, UK |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lyon |D Helen |u Harvard Medical School |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a DeMeo |D Dawn L. |u Brigham and Women |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Raby |D Benjamin |u Harvard Medical School |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Murphy |D Amy |u Harvard School of Public Health |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Silverman |D Edwin K. |u Brigham and Women |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a MacGregor |D Alex |u St Thomas' Hospital, London |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Weiss |D Scott T. |u Harvard Medical School |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Laird |D Nan M. |u Harvard School of Public Health |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Statistical Applications in Genetics and Molecular Biology |d De Gruyter |g 3/1(2004-08-12), 1-27 |q 3:1<1 |1 2004 |2 3 |o sagmb | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||