caa a22 4500 378925946 CHVBK 20180305123617.0 cr unu---uuuuu 161128e20040930xx s 000 0 eng 10.2202/1544-6115.1065 doi (NATIONALLICENCE)gruyter-10.2202/1544-6115.1065 Mammalian Genomes Ease Location of Human DNA Functional Segments but Not Their Description [Elektronische Daten] [Lee A Newberg, Charles E Lawrence] Under the assumption that a significant motivation for sequencing the genomes of mammals is the resulting ability to help us locate and characterize functional DNA segments shared with humans, we have developed a statistical analysis to quantify the expected advantage. Examining uncertainty in terms of the width of a confidence interval, we show that uncertainty in the rate of nucleotide mutation can be shrunk by a factor of nearly four when nine mammals; human, chimpanzee, baboon, cat, dog, cow, pig, rat, mouse; are used instead of just two; human and mouse. Contrastingly, we show confidence interval shrinkage by a factor of only 1.5 for measurements of the distribution of nucleotides at an aligned sequence site. These additional genomes should greatly help in identifying conserved DNA sites, but would be much less effective at precisely describing the expected pattern of nucleotides at those sites. ©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston Computational Biology/Bioinformatics nationallicence Comparative genomics nationallicence Sequence Conservation nationallicence Sequence pattern identification nationallicence Newberg Lee A. New York State Department of Health Wadsworth Center & Rensselaer Polytechnic Institute Department of Computer Science aut Lawrence Charles E. Brown University Division of Applied Mathematics aut Statistical Applications in Genetics and Molecular Biology De Gruyter 3/1(2004-09-30), 1-12 3:1<1 2004 3 sagmb https://doi.org/10.2202/1544-6115.1065 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.2202/1544-6115.1065 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Newberg Lee A. New York State Department of Health Wadsworth Center & Rensselaer Polytechnic Institute Department of Computer Science aut NATIONALLICENCE 700 1- Lawrence Charles E. Brown University Division of Applied Mathematics aut NATIONALLICENCE 773 0- Statistical Applications in Genetics and Molecular Biology De Gruyter 3/1(2004-09-30), 1-12 3:1<1 2004 3 sagmb CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter