caa a22 4500 37892611X CHVBK 20180305123617.0 cr unu---uuuuu 161128e20040519xx s 000 0 eng 10.2202/1544-6115.1043 doi (NATIONALLICENCE)gruyter-10.2202/1544-6115.1043 Bickel David R. Medical College of Georgia (currently at Pioneer Hi-Bred International) Error-Rate and Decision-Theoretic Methods of Multiple Testing: Which Genes Have High Objective Probabilities of Differential Expression? [Elektronische Daten] [David R. Bickel] Given a multiple testing situation, the null hypotheses that appear to have sufficiently low probabilities of truth may be rejected using a simple, nonparametric method based on decision theory. This applies not only to posterior levels of belief, but also to conditional probabilities in the sense of relative frequencies, as seen from their equality to local false discovery rates (dFDRs). This approach neither requires the estimation of probability densities, nor of their ratios. Decision theory can also inform the selection of false discovery rate weights. An application to gene expression microarrays is presented with a discussion of the applicability of the assumption of "clumpy dependence." ©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston Microarrays nationallicence Statistical Theory and Methods nationallicence Proportion of false positives nationallicence positive false discovery rate nationallicence nonparametric empirical Bayes nationallicence gene expression nationallicence multiple hypotheses nationallicence multiple comparisons nationallicence Statistical Applications in Genetics and Molecular Biology De Gruyter 3/1(2004-05-19), 1-20 3:1<1 2004 3 sagmb https://doi.org/10.2202/1544-6115.1043 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.2202/1544-6115.1043 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Bickel David R. Medical College of Georgia (currently at Pioneer Hi-Bred International) NATIONALLICENCE 773 0- Statistical Applications in Genetics and Molecular Biology De Gruyter 3/1(2004-05-19), 1-20 3:1<1 2004 3 sagmb CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter