caa a22 4500 378926152 CHVBK 20180305123618.0 cr unu---uuuuu 161128e20040617xx s 000 0 mul 10.1515/LabMed.2004.027 doi (NATIONALLICENCE)gruyter-10.1515/LabMed.2004.027 Anwendungsgebiete der Massenspektrometrie in der Klinischen Chemie und Laboratoriumsmedizin [Elektronische Daten] Application of mass spectrometry in clinical chemistry and laboratory medicine / [G.M. Fiedler, U. Ceglarek, J. Lembcke, S. Baumann, A. Leichtle, J. Thiery] The use of mass spectrometry (MS) as an analytical tool becomes increasingly important in clinical laboratory diagnostics. In the last decade there has been an exponential growth in clinical laboratory, pharmacology, and toxicology applications. At present, the spectrum of MS applications ranges from the measurement of single analytes to qualitative and quantitative multiparametric analyses. Combining tandem mass spectrometry with atmospheric pressure ionization techniques offers high analytic sensitivity and specificity, robustness, and the option for high throughput analyses at low running costs. Today, this analytical platform is already used in routine clinical laboratory to screen for inherited metabolic disorders in newborns, for therapeutic drug monitoring, and for hormone profiling. In addition, SELDI-TOF and MALDI-TOF techniques are used for clinical proteomic pattern diagnostics. This short review will give an overview of the current status of mass spectrometry techniques, established applications in clinical laboratory diagnostics, and the perspectives for future developments in laboratory medicine. Copyright © 2004 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Fiedler G.M. aut Ceglarek U. aut Lembcke J. aut Baumann S. aut Leichtle A. aut Thiery J. aut LaboratoriumsMedizin Walter de Gruyter 28/3(2004-06-17), 185-194 0342-3026 28:3<185 2004 28 labm https://doi.org/10.1515/LabMed.2004.027 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/LabMed.2004.027 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fiedler G.M. aut NATIONALLICENCE 700 1- Ceglarek U. aut NATIONALLICENCE 700 1- Lembcke J. aut NATIONALLICENCE 700 1- Baumann S. aut NATIONALLICENCE 700 1- Leichtle A. aut NATIONALLICENCE 700 1- Thiery J. aut NATIONALLICENCE 773 0- LaboratoriumsMedizin Walter de Gruyter 28/3(2004-06-17), 185-194 0342-3026 28:3<185 2004 28 labm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter