caa a22 4500 378926195 CHVBK 20180305123618.0 cr unu---uuuuu 161128e20040617xx s 000 0 mul 10.1515/LabMed.2004.032 doi (NATIONALLICENCE)gruyter-10.1515/LabMed.2004.032 Genexpressionsanalysen bei akuten Leukämien: Diagnostik der Zukunft? [Elektronische Daten] Gene expression profiling in acute leukemia: diagnostics of the future? / [T. Haferlach, A. Kohlmann, S. Schnittger, M. Dugas, W. Kern, C. Schoch] A comprehensive diagnosis in leukemia relies on a combination of several methods. Cytomorphology, cytochemistry, cytogenetics, fluorescence in situ hybridization, multiparameter flow cytometry, and molecular methods are applied in parallel. Recently, gene expression profiling using microarrays has made it possible to measure the expression of thousands of genes in one step. The respective specific signature leads to a molecular fingerprint of the tumor sample. Therefore, gene expression profiling may lead to a better molecular classification, insights into pathophysiology of malignant and benign diseases as well as to new treatment options. This can be approached best by using well-defined tumor subtypes. Thus, leukemias are a very informative model system. Furthermore, gene expression profiling may lead to new targeted therapies and can detect genes to be used for minimal residual disease studies. Very recent studies also mention the possibility of using gene expression profiling for prognostication. In conclusion, microarrays may lead to a single platform for leukemia diagnosis with quick and very robust and even cheaper results. Therefore, this new method should be further validated in parallel to the standard work-flow and has to be proven before substituting other methods in the future. Copyright © 2004 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Haferlach T. aut Kohlmann A. aut Schnittger S. aut Dugas M. aut Kern W. aut Schoch C. aut LaboratoriumsMedizin Walter de Gruyter 28/3(2004-06-17), 225-232 0342-3026 28:3<225 2004 28 labm https://doi.org/10.1515/LabMed.2004.032 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/LabMed.2004.032 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Haferlach T. aut NATIONALLICENCE 700 1- Kohlmann A. aut NATIONALLICENCE 700 1- Schnittger S. aut NATIONALLICENCE 700 1- Dugas M. aut NATIONALLICENCE 700 1- Kern W. aut NATIONALLICENCE 700 1- Schoch C. aut NATIONALLICENCE 773 0- LaboratoriumsMedizin Walter de Gruyter 28/3(2004-06-17), 225-232 0342-3026 28:3<225 2004 28 labm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter