caa a22 4500 378926209 CHVBK 20180305123618.0 cr unu---uuuuu 161128e20040617xx s 000 0 mul 10.1515/LabMed.2004.042 doi (NATIONALLICENCE)gruyter-10.1515/LabMed.2004.042 Topical immunomodulators in the treatment of atopic dermatitis [Elektronische Daten] Topische Immunmodulatoren bei der Behandlung der atopischen Dermatitis / [K. Breuer, A. Kapp, T. Werfel] Atopic dermatitis is a chronic inflammatory skin disease that often begins in early infancy and runs a course of exacerbation and remission. Over the last decades topical corticosteroids have represented the therapy of choice for the treatment of flares. However, due to potential side effects, topical steroids are not generally accepted by the patients and physicians. The macrolides tacrolimus and pimecrolimus exert their immunomodulatory effects via inhibition of the phosphatase calcineurin, which normally dephosphorylates the transcription factor NF-AT in T-lymphocytes. This leads to a decreased transcription of several proinflammatory cytokines. Moreover, the immunomodulators have shown to influence also mast cells and antigen presenting cells. The proinflammatory effect of Tacrolimus and Pimecrolimus could be confirmed in various clinical studies on children and adult patients with atopic dermatitis. Various reports demonstrate a potential clinical effect also in other cutaneous skin diseases. Copyright © 2004 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Breuer K. aut Kapp A. aut Werfel T. aut LaboratoriumsMedizin Walter de Gruyter 28/3(2004-06-17), 284-287 0342-3026 28:3<284 2004 28 labm https://doi.org/10.1515/LabMed.2004.042 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/LabMed.2004.042 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Breuer K. aut NATIONALLICENCE 700 1- Kapp A. aut NATIONALLICENCE 700 1- Werfel T. aut NATIONALLICENCE 773 0- LaboratoriumsMedizin Walter de Gruyter 28/3(2004-06-17), 284-287 0342-3026 28:3<284 2004 28 labm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter