caa a22 4500 378926276 CHVBK 20180305123618.0 cr unu---uuuuu 161128e20040617xx s 000 0 mul 10.1515/LabMed.2004.028 doi (NATIONALLICENCE)gruyter-10.1515/LabMed.2004.028 Vogeser M. Anwendung der HPLC-Tandem-Massenspektrometrie in der klinischen Chemie [Elektronische Daten] The use of HPLC-tandem mass spectrometry in clinical chemistry / [M. Vogeser] The technology of liquid chromatography-tandem mass spectrometry opens the perspective of a more widespread use of highly specific mass spectrometric assays in a routine clinical laboratory setting as compared to gas chromatography-mass spectrometry. After the first years of routine application of liquid chromatography-tandem mass spectrometry in a growing number of laboratories, it has become evident that this technique will become a substantial part of the methodological spectrum of laboratory medicine. This is due to the very wide range of potential analytes to be measured with no limitation by molecular mass, the straightforward sample preparation not requiring chemical derivatization and due to the rugged instrumentation with limited maintenance requirements. This review gives a survey of the technical principles of liquid chromatography-tandem mass spectrometry, describes the basics of method development and typical routine applications, discusses strengths and limitations of the technique, and highlights the perspectives for future developments of the technology. Copyright (c) 2004 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence LaboratoriumsMedizin Walter de Gruyter 28/3(2004-06-17), 195-204 0342-3026 28:3<195 2004 28 labm https://doi.org/10.1515/LabMed.2004.028 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/LabMed.2004.028 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Vogeser M. NATIONALLICENCE 773 0- LaboratoriumsMedizin Walter de Gruyter 28/3(2004-06-17), 195-204 0342-3026 28:3<195 2004 28 labm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence SWISSBIB 378926276 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter