caa a22 4500 37893158X CHVBK 20180305123631.0 cr unu---uuuuu 161128e20040101xx s 000 0 eng 10.1351/pac200476040697 doi (NATIONALLICENCE)gruyter-10.1351/pac200476040697 Alemu Hailemichael Department of Chemistry, National University of Lesotho, P.O.Roma 180, Room 127, Roma, Lesotho Voltammetry of drugs at the interface between two immiscible electrolyte solutions [Elektronische Daten] [Hailemichael Alemu] In this review, the results of the electrochemical investigations made on the transfer of ionizable drugs at the interface between two immiscible electrolyte solutions (ITIES) in the last decade have been presented. In many of the studies, cyclic voltammetry has been used to investigate the transfer characteristics of the charged species and deduce their partition coefficients, which are very important parameters to infer the lipophilicity of drugs in biological systems. The electrochemical technique allows the precise determination of the distribution of ionic species between two phases in a wider pH range. Such studies point out the complexity of the distribution of ionizable compounds and offer a new approach to relate the structure of such compounds to their passive transport across biological membranes. © 2013 Walter de Gruyter GmbH, Berlin/Boston Pure and Applied Chemistry De Gruyter 76/4(2004-01-01), 697-705 0033-4545 76:4<697 2004 76 pac https://doi.org/10.1351/pac200476040697 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1351/pac200476040697 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Alemu Hailemichael Department of Chemistry, National University of Lesotho, P.O.Roma 180, Room 127, Roma, Lesotho NATIONALLICENCE 773 0- Pure and Applied Chemistry De Gruyter 76/4(2004-01-01), 697-705 0033-4545 76:4<697 2004 76 pac CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter