caa a22 4500 37893161X CHVBK 20180305123631.0 cr unu---uuuuu 161128e20040101xx s 000 0 eng 10.1351/pac200476040753 doi (NATIONALLICENCE)gruyter-10.1351/pac200476040753 Protein adsorption to planar electrochemical sensors and sensor materials [Elektronische Daten] [Caroline Lim, S. Slack, S. Ufer, E. Lindner] In electrochemical sensing devices, aimed for acute and chronic in vivo application, the active surface of the sensor is often negligible compared to the overall surface area of the device in contact with the biological host. Consequently, to minimize the perturbation of an implanted sensor on the in vivo environment the chemical composition and surface texturing of the complete device (the active sensor, sensor substrate, and "accessories”) have to be considered. In our work, the adsorption of three abundant proteins (albumin, IgG, and fibrinogen) was determined quantitatively on untreated and modified sensor substrates and sensing membrane surfaces. In this study, a flexible polyimide-based material (Kapton ®) was used as sensor substrate with or without an amorphous diamond-like carbon (DLC) or an amorphous oxygen-containing DLC (o-DLC) coating. The ion-sensitive membranes were cast from high-molecular-weight (HMW) or carboxylated poly(vinyl chloride) (PVC) and were doped with increasing concentrations of highly hydrophilic poly(ethylene oxide) (PEO). The potentiometric characteristics of the potassium-selective membranes cast with up to 6 % PEO were the same as those without PEO. However, the PEO-modified PVC membranes elicited a large amount of protein adsorption, especially in terms of albumin. © 2013 Walter de Gruyter GmbH, Berlin/Boston Lim Caroline Joint Graduate Program in Biomedical Engineering, Department of Biomedical Engineering, The University of Memphis, Memphis, TN 38152, USA; Premitec Inc., Venture II, Suite 101, 920 Main Campus Drive, Raleigh, NC 27606, USA aut Slack S. Joint Graduate Program in Biomedical Engineering, Department of Biomedical Engineering, The University of Memphis, Memphis, TN 38152, USA; Premitec Inc., Venture II, Suite 101, 920 Main Campus Drive, Raleigh, NC 27606, USA aut Ufer S. Joint Graduate Program in Biomedical Engineering, Department of Biomedical Engineering, The University of Memphis, Memphis, TN 38152, USA; Premitec Inc., Venture II, Suite 101, 920 Main Campus Drive, Raleigh, NC 27606, USA aut Lindner E. Joint Graduate Program in Biomedical Engineering, Department of Biomedical Engineering, The University of Memphis, Memphis, TN 38152, USA; Premitec Inc., Venture II, Suite 101, 920 Main Campus Drive, Raleigh, NC 27606, USA aut Pure and Applied Chemistry De Gruyter 76/4(2004-01-01), 753-763 0033-4545 76:4<753 2004 76 pac https://doi.org/10.1351/pac200476040753 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1351/pac200476040753 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lim Caroline Joint Graduate Program in Biomedical Engineering, Department of Biomedical Engineering, The University of Memphis, Memphis, TN 38152, USA; Premitec Inc., Venture II, Suite 101, 920 Main Campus Drive, Raleigh, NC 27606, USA aut NATIONALLICENCE 700 1- Slack S. Joint Graduate Program in Biomedical Engineering, Department of Biomedical Engineering, The University of Memphis, Memphis, TN 38152, USA; Premitec Inc., Venture II, Suite 101, 920 Main Campus Drive, Raleigh, NC 27606, USA aut NATIONALLICENCE 700 1- Ufer S. Joint Graduate Program in Biomedical Engineering, Department of Biomedical Engineering, The University of Memphis, Memphis, TN 38152, USA; Premitec Inc., Venture II, Suite 101, 920 Main Campus Drive, Raleigh, NC 27606, USA aut NATIONALLICENCE 700 1- Lindner E. Joint Graduate Program in Biomedical Engineering, Department of Biomedical Engineering, The University of Memphis, Memphis, TN 38152, USA; Premitec Inc., Venture II, Suite 101, 920 Main Campus Drive, Raleigh, NC 27606, USA aut NATIONALLICENCE 773 0- Pure and Applied Chemistry De Gruyter 76/4(2004-01-01), 753-763 0033-4545 76:4<753 2004 76 pac CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter