caa a22 4500 378931717 CHVBK 20180305123631.0 cr unu---uuuuu 161128e20040101xx s 000 0 eng 10.1351/pac200476040829 doi (NATIONALLICENCE)gruyter-10.1351/pac200476040829 Marko-Varga G. Department of Analytical Chemistry, Lund University, Box 124, SE-221 00 Lund, Sweden Proteomics principles and challenges [Elektronische Daten] [G. Marko-Varga] Proteomics studies rely on high-resolving separation techniques whereby the biological complexity can be unraveled. Both gel-based and liquid-phase separation principles are needed in order to mine deeper into the low abundant area of the proteins expressed in human cell samples. The expression levels that can be reached today with proteomics technology are still only reaching part of all proteins present in complex biological samples. The challenge to be met is not an easy task and will, in many aspects, be determined by the speed and success whereby the analytical field can make milestone progress. Examples will be given from our research group on proteomics studies, as well as principles and challenges within this research area. © 2013 Walter de Gruyter GmbH, Berlin/Boston Pure and Applied Chemistry De Gruyter 76/4(2004-01-01), 829-837 0033-4545 76:4<829 2004 76 pac https://doi.org/10.1351/pac200476040829 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1351/pac200476040829 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Marko-Varga G. Department of Analytical Chemistry, Lund University, Box 124, SE-221 00 Lund, Sweden NATIONALLICENCE 773 0- Pure and Applied Chemistry De Gruyter 76/4(2004-01-01), 829-837 0033-4545 76:4<829 2004 76 pac CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter