caa a22 4500 378938045 CHVBK 20180305123645.0 cr unu---uuuuu 161128e20040709xx s 000 0 eng 10.1515/JPM.2004.069 doi (NATIONALLICENCE)gruyter-10.1515/JPM.2004.069 Prostaglandin E[1] treatment in patent ductus arteriosus dependent congenital heart defects [Elektronische Daten] [G. Tálosi, M. Katona, K. Rácz, E. Kertész, B. Onozó, S. Túri] Prostaglandin E1 (PGE1) treatment can be life saving in patients suffering from ductus dependent congenital heart defect. We analyzed the indications and side-effects of PGE1 therapy over a five-year period. The purpose of the study was also to examine whether a change in serum electrolyte levels could be detected. Forty-nine patients were treated with PGE1 during this period. PGE1 treatment was indicated by ductus dependent systemic circulation in 16 cases, ductus dependent pulmonary circulation in 17 cases, transposition of the great arteries in 13 cases and pulmonary hypertension (persistent fetal circulation) in three cases. As early side-effects of the treatment, fever occurred in 27/49 cases while apnoea was observed in 15 patients. In a one-week-old neonate with coarctation of the aorta grade III intraventricular hemorrhage developed. A mild decrease of sodium, potassium and chloride levels and a slight shift of pH levels toward metabolic alkalosis could be detected after one day and one week of PGE1 treatment. Because of these side-effects of PGE1 patients should be monitored in an intensive care unit. According to our observations electrolyte levels may exhibit a slight decrease; however, in the case of a short-term therapy extra salt supplementation is not necessary. Copyright (c) 2004 by Walter de Gruyter GmbH & Co. KG Human reproduction, growth & development nationallicence Gynaecology & obstetrics nationallicence Paediatric medicine nationallicence Tálosi G. aut Katona M. aut Rácz K. aut Kertész E. aut Onozó B. aut Túri S. aut Journal of Perinatal Medicine Walter de Gruyter 32/4(2004-07-09), 368-374 0300-5577 32:4<368 2004 32 jpme https://doi.org/10.1515/JPM.2004.069 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/JPM.2004.069 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tálosi G. aut NATIONALLICENCE 700 1- Katona M. aut NATIONALLICENCE 700 1- Rácz K. aut NATIONALLICENCE 700 1- Kertész E. aut NATIONALLICENCE 700 1- Onozó B. aut NATIONALLICENCE 700 1- Túri S. aut NATIONALLICENCE 773 0- Journal of Perinatal Medicine Walter de Gruyter 32/4(2004-07-09), 368-374 0300-5577 32:4<368 2004 32 jpme CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter