Anti-hypertensive therapy and the feto-placental circulation: effects on umbilical artery resistance
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| 024 | 7 | 0 | |a 10.1515/JPM.2004.058 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/JPM.2004.058 | ||
| 245 | 0 | 0 | |a Anti-hypertensive therapy and the feto-placental circulation: effects on umbilical artery resistance |h [Elektronische Daten] |c [D.D. Houlihan, M.C. Dennedy, N. Ravikumar, J.J. Morrison] |
| 520 | 3 | |a Objective: To investigate and compare the direct effects of compounds used in the treatment of hypertensive disease in pregnancy on human umbilical artery resistance in vitro. Methods: Isometric tension recordings were performed under physiological conditions on human umbilical arterial rings (n=30). The in vitro effects of labetolol, hydralazine, alpha-methyldopa, nifedepine and magnesium sulphate (at concentration ranges from 1 nanomolar to 1 millimolar), and their respective vehicle controls, were measured. Results were expressed as −logEC50 (pD2) and mean maximal inhibition values for each compound. Results: All compounds investigated, except alpha methyldopa, exerted a significant relaxant effect on umbilical arterial tone. Alpha-methyldopa was significantly less potent when compared to all other compounds (mean maximal inhibition value [20.89±7.99%] versus all other agents [range 63.15±8.70−84.12±3.84%] (P<0.01)). The dose response curve of nifedipine yielded a significantly greater pD2 value when compared to that of hydralazine, labetalol, and magnesium sulphate (pD2 value [5.82±0.34] versus the above groups [range 3.10±0.09−3.52±0.14] (P<0.01)). Conclusion: These findings demonstrate that agents commonly used for the treatment of hypertensive disease in pregnancy, excluding alpha-methyldopa, have significant direct effects on the feto-placental circulation. These results suggest that alpha-methyldopa administration during pregnancy is less likely to produce significant direct effects on fetal vasculature then other agents used. | |
| 540 | |a Copyright © 2004 by Walter de Gruyter GmbH & Co. KG | ||
| 690 | 7 | |a Human reproduction, growth & development |2 nationallicence | |
| 690 | 7 | |a Gynaecology & obstetrics |2 nationallicence | |
| 690 | 7 | |a Paediatric medicine |2 nationallicence | |
| 700 | 1 | |a Houlihan |D D.D. |4 aut | |
| 700 | 1 | |a Dennedy |D M.C. |4 aut | |
| 700 | 1 | |a Ravikumar |D N. |4 aut | |
| 700 | 1 | |a Morrison |D J.J. |4 aut | |
| 773 | 0 | |t Journal of Perinatal Medicine |d Walter de Gruyter |g 32/4(2004-07-09), 315-319 |x 0300-5577 |q 32:4<315 |1 2004 |2 32 |o jpme | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/JPM.2004.058 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/JPM.2004.058 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Houlihan |D D.D. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Dennedy |D M.C. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ravikumar |D N. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Morrison |D J.J. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Perinatal Medicine |d Walter de Gruyter |g 32/4(2004-07-09), 315-319 |x 0300-5577 |q 32:4<315 |1 2004 |2 32 |o jpme | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||