caa a22 4500 378938096 CHVBK 20180305123645.0 cr unu---uuuuu 161128e20040709xx s 000 0 eng 10.1515/JPM.2004.058 doi (NATIONALLICENCE)gruyter-10.1515/JPM.2004.058 Anti-hypertensive therapy and the feto-placental circulation: effects on umbilical artery resistance [Elektronische Daten] [D.D. Houlihan, M.C. Dennedy, N. Ravikumar, J.J. Morrison] Objective: To investigate and compare the direct effects of compounds used in the treatment of hypertensive disease in pregnancy on human umbilical artery resistance in vitro. Methods: Isometric tension recordings were performed under physiological conditions on human umbilical arterial rings (n=30). The in vitro effects of labetolol, hydralazine, alpha-methyldopa, nifedepine and magnesium sulphate (at concentration ranges from 1 nanomolar to 1 millimolar), and their respective vehicle controls, were measured. Results were expressed as −logEC50 (pD2) and mean maximal inhibition values for each compound. Results: All compounds investigated, except alpha methyldopa, exerted a significant relaxant effect on umbilical arterial tone. Alpha-methyldopa was significantly less potent when compared to all other compounds (mean maximal inhibition value [20.89±7.99%] versus all other agents [range 63.15±8.70−84.12±3.84%] (P<0.01)). The dose response curve of nifedipine yielded a significantly greater pD2 value when compared to that of hydralazine, labetalol, and magnesium sulphate (pD2 value [5.82±0.34] versus the above groups [range 3.10±0.09−3.52±0.14] (P<0.01)). Conclusion: These findings demonstrate that agents commonly used for the treatment of hypertensive disease in pregnancy, excluding alpha-methyldopa, have significant direct effects on the feto-placental circulation. These results suggest that alpha-methyldopa administration during pregnancy is less likely to produce significant direct effects on fetal vasculature then other agents used. Copyright © 2004 by Walter de Gruyter GmbH & Co. KG Human reproduction, growth & development nationallicence Gynaecology & obstetrics nationallicence Paediatric medicine nationallicence Houlihan D.D. aut Dennedy M.C. aut Ravikumar N. aut Morrison J.J. aut Journal of Perinatal Medicine Walter de Gruyter 32/4(2004-07-09), 315-319 0300-5577 32:4<315 2004 32 jpme https://doi.org/10.1515/JPM.2004.058 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/JPM.2004.058 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Houlihan D.D. aut NATIONALLICENCE 700 1- Dennedy M.C. aut NATIONALLICENCE 700 1- Ravikumar N. aut NATIONALLICENCE 700 1- Morrison J.J. aut NATIONALLICENCE 773 0- Journal of Perinatal Medicine Walter de Gruyter 32/4(2004-07-09), 315-319 0300-5577 32:4<315 2004 32 jpme CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter