Evidence of fetal pulmonary aspiration of intra-amniotic administered surfactant in animal experiment
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| 024 | 7 | 0 | |a 10.1515/JPM.2004.066 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/JPM.2004.066 | ||
| 245 | 0 | 0 | |a Evidence of fetal pulmonary aspiration of intra-amniotic administered surfactant in animal experiment |h [Elektronische Daten] |c [R. Illia, C. Solana, P. Oliveri, J. Toblli, M.U. Imaz, D. Häbich] |
| 520 | 3 | |a Introduction: The instillation of surfactant into the airways of patients with respiratory distress syndrome (RDS), especially in the neonatal period, is a proven therapy. The preventive therapy of RDS through intra-amniotic injection of surfactant has been reported recently. It has not been conclusively shown, however, that the surfactant administered in this way actually reaches the fetal pulmonary airways. Objective: To study the distribution in fetal organs of a natural surfactant labeled with technetium-99m and injected through amniocentesis into the amniotic sac of guinea pigs in the last third of pregnancy. Methods: After stimulating fetal respiratory movements with aminophylline 0.3 ml of an aqueous suspension containing 0.75 mg of phospholipids of a natural bovine surfactant labeled with technetium-99m, together with 0.1 ml of the biological dye carmine indigo, were injected into the amniotic sac. One hour later fetuses were delivered by cesarean section. In those that were dye-stained, dosimetric and gammagraphic tests were applied to trachea, lungs, esophagus, stomach, heart, liver, kidneys and placenta. Results: Significant radio isotopic activity was found in both lungs of six treated fetuses, with a dose capture of between 1.0% and 5.3% of total dose. The level of activity in the stomachs was similar to that in the lungs (0.9% to 3.0% dose capture), whereas activity in other organs was negligible except in two placentae. No radio isotopic activity was found in non-injected control fetuses. Conclusions: In the present animal model natural surfactant injected intra-amniotically is aspirated into the lungs within one hour. | |
| 540 | |a Copyright © 2004 by Walter de Gruyter GmbH & Co. KG | ||
| 690 | 7 | |a Human reproduction, growth & development |2 nationallicence | |
| 690 | 7 | |a Gynaecology & obstetrics |2 nationallicence | |
| 690 | 7 | |a Paediatric medicine |2 nationallicence | |
| 700 | 1 | |a Illia |D R. |4 aut | |
| 700 | 1 | |a Solana |D C. |4 aut | |
| 700 | 1 | |a Oliveri |D P. |4 aut | |
| 700 | 1 | |a Toblli |D J. |4 aut | |
| 700 | 1 | |a Imaz |D M.U. |4 aut | |
| 700 | 1 | |a Häbich |D D. |4 aut | |
| 773 | 0 | |t Journal of Perinatal Medicine |d Walter de Gruyter |g 32/4(2004-07-09), 354-358 |x 0300-5577 |q 32:4<354 |1 2004 |2 32 |o jpme | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/JPM.2004.066 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/JPM.2004.066 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Illia |D R. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Solana |D C. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Oliveri |D P. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Toblli |D J. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Imaz |D M.U. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Häbich |D D. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Perinatal Medicine |d Walter de Gruyter |g 32/4(2004-07-09), 354-358 |x 0300-5577 |q 32:4<354 |1 2004 |2 32 |o jpme | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
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| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||