caa a22 4500 378939173 CHVBK 20180305123648.0 cr unu---uuuuu 161128e20040930xx s 000 0 eng 10.1351/pac200476091781 doi (NATIONALLICENCE)gruyter-10.1351/pac200476091781 Postgenomic chemistry: New problems and challenges [Elektronische Daten] [S. D. Varfolomeyev, T. K. Aliev, E. N. Efremenko] New trends in chemistry induced by genetic engineering and genomic information are analyzed. Genomic information and bioinformatics make the identification of all molecular participants of biological processes possible. The methods of identification of enzyme-active sites from sequence data were demonstrated. The problems of "chemical proteomics" were formulated and analyzed. New biocatalytic processes based on a new generation of enzymes, including CO2 reduction and enzyme fuel cell construction, are demonstrated. It was shown that in many reactions the enzymes are substantially more efficient in comparison with classical chemical catalysts. The creation of recombinant proteins from unnatural amino acids is demonstrated, and organisms containing such proteins are described. The new trends of proteomics and bioanalytical chemistry in the postgenomic era are discussed. © 2013 Walter de Gruyter GmbH, Berlin/Boston Varfolomeyev S. D. The Lomonosov Moscow State University, Faculty of Chemistry, Chemical Enzymology Department, Lenin's Hills, 1/11, Moscow 119992, Russia aut Aliev T. K. The Lomonosov Moscow State University, Faculty of Chemistry, Chemical Enzymology Department, Lenin's Hills, 1/11, Moscow 119992, Russia aut Efremenko E. N. The Lomonosov Moscow State University, Faculty of Chemistry, Chemical Enzymology Department, Lenin's Hills, 1/11, Moscow 119992, Russia aut Pure and Applied Chemistry De Gruyter 76/9(2004-09-30), 1781-1798 0033-4545 76:9<1781 2004 76 pac https://doi.org/10.1351/pac200476091781 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1351/pac200476091781 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Varfolomeyev S. D. The Lomonosov Moscow State University, Faculty of Chemistry, Chemical Enzymology Department, Lenin's Hills, 1/11, Moscow 119992, Russia aut NATIONALLICENCE 700 1- Aliev T. K. The Lomonosov Moscow State University, Faculty of Chemistry, Chemical Enzymology Department, Lenin's Hills, 1/11, Moscow 119992, Russia aut NATIONALLICENCE 700 1- Efremenko E. N. The Lomonosov Moscow State University, Faculty of Chemistry, Chemical Enzymology Department, Lenin's Hills, 1/11, Moscow 119992, Russia aut NATIONALLICENCE 773 0- Pure and Applied Chemistry De Gruyter 76/9(2004-09-30), 1781-1798 0033-4545 76:9<1781 2004 76 pac CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter