Simulation of proteasomal protein degradation by the Monte Carlo method
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| 024 | 7 | 0 | |a 10.1515/1569398042395998 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/1569398042395998 | ||
| 245 | 0 | 0 | |a Simulation of proteasomal protein degradation by the Monte Carlo method |h [Elektronische Daten] |c [V. S. Antyufeev, S. V. Nikolaev] |
| 520 | 3 | |a The proteasomal proteolysis is assumed to be the main pathway of protein degradation in a cell. The studies of the proteasome structure and experiments in the proteasomal proteolysis of proteins in vitro raised questions regarding details of this process. We can attempt to elucidate them by computer simulation. We propose the model of the proteasomal proteolysis process of proteins in vitro and carry out computer experiments with it. We develop an algorithm for the direct simulation of the process by the model proposed. The mathematical results obtained allow us to appreciably reduce the computing time of the direct simulation. The form of the distribution curve of the lengths of protein segments, which was obtained in the calculations, coincides with that of the experimental curve. The explanation for the form of the curve corroborates the model chosen. | |
| 540 | |a Copyright 2004, Walter de Gruyter | ||
| 700 | 1 | |a Antyufeev |D V. S. |u Institute of Computational Mathematics and Mathematical Geophysics, Siberian Branch of theRussian Academy of Sciences, Novosibirsk 630090, Russia |4 aut | |
| 700 | 1 | |a Nikolaev |D S. V. |u Institute of Cytology and Genetics, Novosibirsk 630090, Russia |4 aut | |
| 773 | 0 | |t Russian Journal of Numerical Analysis and Mathematical Modelling |d Walter de Gruyter |g 19/5(2004-10-01), 387-406 |x 0927-6467 |q 19:5<387 |1 2004 |2 19 |o rnam | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/1569398042395998 |q text/html |z Onlinezugriff via DOI |
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/1569398042395998 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Antyufeev |D V. S. |u Institute of Computational Mathematics and Mathematical Geophysics, Siberian Branch of theRussian Academy of Sciences, Novosibirsk 630090, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nikolaev |D S. V. |u Institute of Cytology and Genetics, Novosibirsk 630090, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Russian Journal of Numerical Analysis and Mathematical Modelling |d Walter de Gruyter |g 19/5(2004-10-01), 387-406 |x 0927-6467 |q 19:5<387 |1 2004 |2 19 |o rnam | ||
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| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||