caa a22 4500 378939939 CHVBK 20180305123649.0 cr unu---uuuuu 161128e20041001xx s 000 0 eng 10.1515/1569398042395998 doi (NATIONALLICENCE)gruyter-10.1515/1569398042395998 Simulation of proteasomal protein degradation by the Monte Carlo method [Elektronische Daten] [V. S. Antyufeev, S. V. Nikolaev] The proteasomal proteolysis is assumed to be the main pathway of protein degradation in a cell. The studies of the proteasome structure and experiments in the proteasomal proteolysis of proteins in vitro raised questions regarding details of this process. We can attempt to elucidate them by computer simulation. We propose the model of the proteasomal proteolysis process of proteins in vitro and carry out computer experiments with it. We develop an algorithm for the direct simulation of the process by the model proposed. The mathematical results obtained allow us to appreciably reduce the computing time of the direct simulation. The form of the distribution curve of the lengths of protein segments, which was obtained in the calculations, coincides with that of the experimental curve. The explanation for the form of the curve corroborates the model chosen. Copyright 2004, Walter de Gruyter Antyufeev V. S. Institute of Computational Mathematics and Mathematical Geophysics, Siberian Branch of theRussian Academy of Sciences, Novosibirsk 630090, Russia aut Nikolaev S. V. Institute of Cytology and Genetics, Novosibirsk 630090, Russia aut Russian Journal of Numerical Analysis and Mathematical Modelling Walter de Gruyter 19/5(2004-10-01), 387-406 0927-6467 19:5<387 2004 19 rnam https://doi.org/10.1515/1569398042395998 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/1569398042395998 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Antyufeev V. S. Institute of Computational Mathematics and Mathematical Geophysics, Siberian Branch of theRussian Academy of Sciences, Novosibirsk 630090, Russia aut NATIONALLICENCE 700 1- Nikolaev S. V. Institute of Cytology and Genetics, Novosibirsk 630090, Russia aut NATIONALLICENCE 773 0- Russian Journal of Numerical Analysis and Mathematical Modelling Walter de Gruyter 19/5(2004-10-01), 387-406 0927-6467 19:5<387 2004 19 rnam CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter