caa a22 4500 378941046 CHVBK 20180305123652.0 cr unu---uuuuu 161128e20041001xx s 000 0 eng 10.1515/BC.2004.118 doi (NATIONALLICENCE)gruyter-10.1515/BC.2004.118 Imprinted small RNA genes [Elektronische Daten] [Hervé Seitz, Hélène Royo, Shau-Ping Lin, Neil Youngson, Anne C. Ferguson-Smith, Jérôme Cavaillé] Genomic imprinting is an epigenetic phenomenon that results in differential expression of both alleles, depending on their parent of origin. We have recently identified many imprinted small non-coding RNA genes belonging to the C/D RNA and microRNA gene families, both of which are usually known to play key roles in post-transcriptional metabolism of specific genes (e.g. C/D RNAs guide ribose methylation of target RNAs while microRNAs elicit either translational repression or RNA interference). Although the functional and evolutionary significance of this association between C/D RNA genes, microRNA genes and genomic imprinting is still highly elusive, these observations provide a framework for further analysis of the potential role of small non-coding RNAs in epigenetic control. © Walter de Gruyter Biochemistry nationallicence Molecular biology nationallicence Cellular biology nationallicence genomic imprinting nationallicence microRNAs nationallicence non-coding RNAs nationallicence snoRNAs nationallicence Seitz Hervé Laboratoire de Biologie Moléculaire des Eucaryotes du CNRS, Institut d'Exploration Fonctionnelle des Génomes, 118 route de Narbonne, F-31062 Toulouse Cedex 4, France aut Royo Hélène Laboratoire de Biologie Moléculaire des Eucaryotes du CNRS, Institut d'Exploration Fonctionnelle des Génomes, 118 route de Narbonne, F-31062 Toulouse Cedex 4, France aut Lin Shau-Ping Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK aut Youngson Neil Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK aut Ferguson-Smith Anne C. Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK aut Cavaillé Jérôme Laboratoire de Biologie Moléculaire des Eucaryotes du CNRS, Institut d'Exploration Fonctionnelle des Génomes, 118 route de Narbonne, F-31062 Toulouse Cedex 4, France aut Biological Chemistry Walter de Gruyter 385/10(2004-10-01), 905-911 1431-6730 385:10<905 2004 385 bchm https://doi.org/10.1515/BC.2004.118 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/BC.2004.118 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Seitz Hervé Laboratoire de Biologie Moléculaire des Eucaryotes du CNRS, Institut d'Exploration Fonctionnelle des Génomes, 118 route de Narbonne, F-31062 Toulouse Cedex 4, France aut NATIONALLICENCE 700 1- Royo Hélène Laboratoire de Biologie Moléculaire des Eucaryotes du CNRS, Institut d'Exploration Fonctionnelle des Génomes, 118 route de Narbonne, F-31062 Toulouse Cedex 4, France aut NATIONALLICENCE 700 1- Lin Shau-Ping Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK aut NATIONALLICENCE 700 1- Youngson Neil Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK aut NATIONALLICENCE 700 1- Ferguson-Smith Anne C. Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK aut NATIONALLICENCE 700 1- Cavaillé Jérôme Laboratoire de Biologie Moléculaire des Eucaryotes du CNRS, Institut d'Exploration Fonctionnelle des Génomes, 118 route de Narbonne, F-31062 Toulouse Cedex 4, France aut NATIONALLICENCE 773 0- Biological Chemistry Walter de Gruyter 385/10(2004-10-01), 905-911 1431-6730 385:10<905 2004 385 bchm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter