Roles of nectins in cell adhesion, migration and polarization
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| 008 | 161128e20041001xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1515/BC.2004.116 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/BC.2004.116 | ||
| 245 | 0 | 0 | |a Roles of nectins in cell adhesion, migration and polarization |h [Elektronische Daten] |c [Hiroyuki Nakanishi, Yoshimi Takai] |
| 520 | 3 | |a Nectins are Ca2+-independent immunoglobulin (Ig)-like cell-cell adhesion molecules, which comprise a family consisting of four members. Nectins have five activities: (1) they show Ca2+-independent cell-cell adhesion activity by homo- and hetero-trans-interactions through their extracellular regions; (2) they bind afadin, an actin filament (F-actin)-binding protein, through their cytoplasmic tails and are connected to the actin cytoskeleton; (3) they induce activation of Cdc42 and Rac small G proteins through their cytoplasmic tails; (4) they bind Par-3, a cell polarity protein, through their cytoplasmic tails; and (5) they heterophilically trans-interact with Necls, nectin-like molecules, through their extracellular regions. Through these activities, nectins regulate a variety of cellular functions, including adhesion, migration, and polarization. Here we describe these activities and functions of nectins. | |
| 540 | |a © Walter de Gruyter | ||
| 690 | 7 | |a Biochemistry |2 nationallicence | |
| 690 | 7 | |a Molecular biology |2 nationallicence | |
| 690 | 7 | |a Cellular biology |2 nationallicence | |
| 690 | 7 | |a cadherins |2 nationallicence | |
| 690 | 7 | |a cell adhesion |2 nationallicence | |
| 690 | 7 | |a cell migration |2 nationallicence | |
| 690 | 7 | |a cell polarization |2 nationallicence | |
| 690 | 7 | |a nectins |2 nationallicence | |
| 690 | 7 | |a Necls |2 nationallicence | |
| 700 | 1 | |a Nakanishi |D Hiroyuki |u Department of Molecular Pharmacology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860-8556, Japan |4 aut | |
| 700 | 1 | |a Takai |D Yoshimi |u Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine/Faculty of Medicine, Suita 565-0871, Japan |4 aut | |
| 773 | 0 | |t Biological Chemistry |d Walter de Gruyter |g 385/10(2004-10-01), 885-892 |x 1431-6730 |q 385:10<885 |1 2004 |2 385 |o bchm | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/BC.2004.116 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/BC.2004.116 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nakanishi |D Hiroyuki |u Department of Molecular Pharmacology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860-8556, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Takai |D Yoshimi |u Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine/Faculty of Medicine, Suita 565-0871, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Biological Chemistry |d Walter de Gruyter |g 385/10(2004-10-01), 885-892 |x 1431-6730 |q 385:10<885 |1 2004 |2 385 |o bchm | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||