caa a22 4500 378941119 CHVBK 20180305123652.0 cr unu---uuuuu 161128e20041001xx s 000 0 eng 10.1515/BC.2004.116 doi (NATIONALLICENCE)gruyter-10.1515/BC.2004.116 Roles of nectins in cell adhesion, migration and polarization [Elektronische Daten] [Hiroyuki Nakanishi, Yoshimi Takai] Nectins are Ca2+-independent immunoglobulin (Ig)-like cell-cell adhesion molecules, which comprise a family consisting of four members. Nectins have five activities: (1) they show Ca2+-independent cell-cell adhesion activity by homo- and hetero-trans-interactions through their extracellular regions; (2) they bind afadin, an actin filament (F-actin)-binding protein, through their cytoplasmic tails and are connected to the actin cytoskeleton; (3) they induce activation of Cdc42 and Rac small G proteins through their cytoplasmic tails; (4) they bind Par-3, a cell polarity protein, through their cytoplasmic tails; and (5) they heterophilically trans-interact with Necls, nectin-like molecules, through their extracellular regions. Through these activities, nectins regulate a variety of cellular functions, including adhesion, migration, and polarization. Here we describe these activities and functions of nectins. © Walter de Gruyter Biochemistry nationallicence Molecular biology nationallicence Cellular biology nationallicence cadherins nationallicence cell adhesion nationallicence cell migration nationallicence cell polarization nationallicence nectins nationallicence Necls nationallicence Nakanishi Hiroyuki Department of Molecular Pharmacology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860-8556, Japan aut Takai Yoshimi Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine/Faculty of Medicine, Suita 565-0871, Japan aut Biological Chemistry Walter de Gruyter 385/10(2004-10-01), 885-892 1431-6730 385:10<885 2004 385 bchm https://doi.org/10.1515/BC.2004.116 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/BC.2004.116 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nakanishi Hiroyuki Department of Molecular Pharmacology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860-8556, Japan aut NATIONALLICENCE 700 1- Takai Yoshimi Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine/Faculty of Medicine, Suita 565-0871, Japan aut NATIONALLICENCE 773 0- Biological Chemistry Walter de Gruyter 385/10(2004-10-01), 885-892 1431-6730 385:10<885 2004 385 bchm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter