Radiolysis of an aqueous [11C]iomazenil solution
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| 024 | 7 | 0 | |a 10.1524/ract.92.2.119.27464 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1524/ract.92.2.119.27464 | ||
| 245 | 0 | 0 | |a Radiolysis of an aqueous [11C]iomazenil solution |h [Elektronische Daten] |c [Toshimitsu Fukumura, Masatoshi Yamaguchi, Kazutoshi Suzuki] |
| 520 | 3 | |a Radiolysis of [11C]iomazenil was investigated in an aqueous solution. Preparation of [11C]iomazenil with [11C]CH3I produced a good radiochemical yield, however, its radiochemical purity was always less than 90 without additives. This poor radiochemical purity was attributed to radiolysis of [11C]iomazenil. The degradation of [11C]iomazenil via radiolysis was markedly facilitated in the presence of HCOONa (strong selective hydroxyl radical and hydrogen atom scavenger). On the other hand, the radiolysis was suppressed effectively in the presence of NaNO3 (selective hydrated electron scavenger), suggesting participation of hydrated electrons in the radiolysis of [11C]iomazenil. LC/MS analysis of the degradation product suggested that the major degradation product by radiolysis had a molecular weight of 285 corresponding to the deiodinated compound. The present study showed that a decrease in the radiochemical purity of [11C]iomazenil was attributed to the radiolysis via the deiodination reaction by hydrated electron. | |
| 540 | |a © 2004 Oldenbourg Wissenschaftsverlag GmbH | ||
| 690 | 7 | |a Laboratory techniques, experiments |2 nationallicence | |
| 690 | 7 | |a Analytical chemistry |2 nationallicence | |
| 690 | 7 | |a Inorganic chemistry |2 nationallicence | |
| 700 | 1 | |a Fukumura |D Toshimitsu |4 aut | |
| 700 | 1 | |a Yamaguchi |D Masatoshi |4 aut | |
| 700 | 1 | |a Suzuki |D Kazutoshi |4 aut | |
| 773 | 0 | |t Radiochimica Acta/International journal for chemical aspects of nuclear science and technology |d Oldenbourg Wissenschaftsverlag GmbH |g 92/2/2004(2004-02-01), 119-123 |x 0033-8230 |q 92:2/2004<119 |1 2004 |2 92 |o ract | |
| 856 | 4 | 0 | |u https://doi.org/10.1524/ract.92.2.119.27464 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1524/ract.92.2.119.27464 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fukumura |D Toshimitsu |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yamaguchi |D Masatoshi |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Suzuki |D Kazutoshi |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Radiochimica Acta/International journal for chemical aspects of nuclear science and technology |d Oldenbourg Wissenschaftsverlag GmbH |g 92/2/2004(2004-02-01), 119-123 |x 0033-8230 |q 92:2/2004<119 |1 2004 |2 92 |o ract | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||