caa a22 4500 378941356 CHVBK 20180305123653.0 cr unu---uuuuu 161128e20040201xx s 000 0 eng 10.1524/ract.92.2.119.27464 doi (NATIONALLICENCE)gruyter-10.1524/ract.92.2.119.27464 Radiolysis of an aqueous [11C]iomazenil solution [Elektronische Daten] [Toshimitsu Fukumura, Masatoshi Yamaguchi, Kazutoshi Suzuki] Radiolysis of [11C]iomazenil was investigated in an aqueous solution. Preparation of [11C]iomazenil with [11C]CH3I produced a good radiochemical yield, however, its radiochemical purity was always less than 90 without additives. This poor radiochemical purity was attributed to radiolysis of [11C]iomazenil. The degradation of [11C]iomazenil via radiolysis was markedly facilitated in the presence of HCOONa (strong selective hydroxyl radical and hydrogen atom scavenger). On the other hand, the radiolysis was suppressed effectively in the presence of NaNO3 (selective hydrated electron scavenger), suggesting participation of hydrated electrons in the radiolysis of [11C]iomazenil. LC/MS analysis of the degradation product suggested that the major degradation product by radiolysis had a molecular weight of 285 corresponding to the deiodinated compound. The present study showed that a decrease in the radiochemical purity of [11C]iomazenil was attributed to the radiolysis via the deiodination reaction by hydrated electron. © 2004 Oldenbourg Wissenschaftsverlag GmbH Laboratory techniques, experiments nationallicence Analytical chemistry nationallicence Inorganic chemistry nationallicence Fukumura Toshimitsu aut Yamaguchi Masatoshi aut Suzuki Kazutoshi aut Radiochimica Acta/International journal for chemical aspects of nuclear science and technology Oldenbourg Wissenschaftsverlag GmbH 92/2/2004(2004-02-01), 119-123 0033-8230 92:2/2004<119 2004 92 ract https://doi.org/10.1524/ract.92.2.119.27464 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1524/ract.92.2.119.27464 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fukumura Toshimitsu aut NATIONALLICENCE 700 1- Yamaguchi Masatoshi aut NATIONALLICENCE 700 1- Suzuki Kazutoshi aut NATIONALLICENCE 773 0- Radiochimica Acta/International journal for chemical aspects of nuclear science and technology Oldenbourg Wissenschaftsverlag GmbH 92/2/2004(2004-02-01), 119-123 0033-8230 92:2/2004<119 2004 92 ract CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter