caa a22 4500 378942298 CHVBK 20180305123655.0 cr unu---uuuuu 161128e20040315xx s 000 0 eng 10.1515/JPM.2004.029 doi (NATIONALLICENCE)gruyter-10.1515/JPM.2004.029 Atypical chronic lung disease in preterm infants [Elektronische Daten] [J. Panickar, H. Scholefield, Y. Kumar, D. W. Pilling, N. V. Subhedar] An atypical pattern of chronic lung disease (CLD) has been described in preterm infants and a potential association with intrauterine inflammation has been proposed. We aimed to describe patterns of CLD, to determine the incidence of atypical CLD, and to compare the distribution of various perinatal factors in infants with classic and atypical CLD. Information about demographics, respiratory status and various perinatal variables was collected for all neonatal admissions <1250 g. CLD was defined as oxygen dependency at 28 days of age. Ninety (51%) survivors at 28 days of age developed CLD; of these 37 (41%) were classified as atypical CLD. Factors significantly and independently associated with development of atypical CLD included being inborn, receiving natural surfactant, fewer days of mechanical ventilation within the first 28 days of life and higher birth-weight. Chorioamnionitis, postnatal infection and symptomatic PDA were not found to be significantly associated with atypical CLD. Atypical CLD is a common pattern of prolonged oxygen dependency in preterm survivors and is a feature of larger, more mature babies. Our findings do not support the hypothesis that exposure to intrauterine inflammation is an important aetiological factor in the development of atypical CLD. Copyright © 2004 by Walter de Gruyter GmbH & Co. KG Human reproduction, growth & development nationallicence Gynaecology & obstetrics nationallicence Paediatric medicine nationallicence Panickar J. aut Scholefield H. aut Kumar Y. aut Pilling D. W. aut Subhedar N. V. aut Journal of Perinatal Medicine Walter de Gruyter 32/2(2004-03-15), 162-167 0300-5577 32:2<162 2004 32 jpme https://doi.org/10.1515/JPM.2004.029 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/JPM.2004.029 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Panickar J. aut NATIONALLICENCE 700 1- Scholefield H. aut NATIONALLICENCE 700 1- Kumar Y. aut NATIONALLICENCE 700 1- Pilling D. W. aut NATIONALLICENCE 700 1- Subhedar N. V. aut NATIONALLICENCE 773 0- Journal of Perinatal Medicine Walter de Gruyter 32/2(2004-03-15), 162-167 0300-5577 32:2<162 2004 32 jpme CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter