Is cervical dilatation during parturition at term associated with apoptosis?
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| 024 | 7 | 0 | |a 10.1515/JPM.2004.025 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/JPM.2004.025 | ||
| 245 | 0 | 0 | |a Is cervical dilatation during parturition at term associated with apoptosis? |h [Elektronische Daten] |c [B. Kemp, W. Rath, M. Winkler, T. Reineke, H.M. Beier, U. von Rango] |
| 520 | 3 | |a Aims: Cellular turnover may be involved in remodeling of the cervix during parturition. Therefore, the number and localization of apoptotic and proliferating cells during cervical dilatation at term were determined. Methods: Biopsy specimens from the lower uterine segment of 36 women undergoing cesarean section with a cervical dilatation of <2 cm (n = 10), 2-<4 cm (n = 9), 4-6 cm (n = 8), and 6 cm (n = 9) were examined for nuclear fragmentation by the TUNEL assay, and for cell survival by the apoptosis-blocking bcl-2. Proliferation was marked by Ki-67, epithelial cells by cytokeratin and leukocytes by CD 45. For quantification of apoptotic and proliferating cells, eight random fields of each specimen stained for TUNEL or Ki-67 were blindly counted by two investigators. For statistical evaluation, 90% confidence intervals based on a Poisson distribution were used; groups with non-overlapping intervals were considered significantly different. Results: Apoptotic cells were found exclusively within the stromal compartment, while bcl-2 was expressed in epithelial cells and leukocytes. Proliferating cells were of stromal and epithelial origin. The number of apoptotic as well as proliferating cells ranged from 0 to 2 cells per high-power field (median number 0) in all groups. The confidence intervals were overlapping for all groups, showing no statistical difference between them. Conclusion: Apoptosis does not seem to play a decisive role in the process of cervical dilatation during parturition at term. | |
| 540 | |a © Walter de Gruyter | ||
| 690 | 7 | |a Human reproduction, growth & development |2 nationallicence | |
| 690 | 7 | |a Gynaecology & obstetrics |2 nationallicence | |
| 690 | 7 | |a Paediatric medicine |2 nationallicence | |
| 690 | 7 | |a Apoptosis |2 nationallicence | |
| 690 | 7 | |a cervical dilatation |2 nationallicence | |
| 690 | 7 | |a cervix |2 nationallicence | |
| 690 | 7 | |a parturition |2 nationallicence | |
| 690 | 7 | |a proliferation |2 nationallicence | |
| 700 | 1 | |a Kemp |D B. |u Department of Obstetrics and Gynecology, University Hospital, Technical University, Aachen, Germany. |4 aut | |
| 700 | 1 | |a Rath |D W. |u Department of Obstetrics and Gynecology, University Hospital, Technical University, Aachen, Germany. |4 aut | |
| 700 | 1 | |a Winkler |D M. |u Department of Obstetrics and Gynecology, University Hospital, Technical University, Aachen, Germany. |4 aut | |
| 700 | 1 | |a Reineke |D T. |u Statistical Institute, Aachen, Germany. |4 aut | |
| 700 | 1 | |a Beier |D H.M. |u Institute of Anatomy and Reproductive Biology, University Hospital, Technical University, Aachen, Germany. |4 aut | |
| 700 | 1 | |a Rango |D U. von |u Institute of Anatomy and Reproductive Biology, University Hospital, Technical University, Aachen, Germany. |4 aut | |
| 773 | 0 | |t Journal of Perinatal Medicine |d Walter de Gruyter |g 32/2(2004-03-01), 137-143 |x 0300-5577 |q 32:2<137 |1 2004 |2 32 |o jpme | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/JPM.2004.025 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/JPM.2004.025 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kemp |D B. |u Department of Obstetrics and Gynecology, University Hospital, Technical University, Aachen, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rath |D W. |u Department of Obstetrics and Gynecology, University Hospital, Technical University, Aachen, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Winkler |D M. |u Department of Obstetrics and Gynecology, University Hospital, Technical University, Aachen, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Reineke |D T. |u Statistical Institute, Aachen, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Beier |D H.M. |u Institute of Anatomy and Reproductive Biology, University Hospital, Technical University, Aachen, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rango |D U. von |u Institute of Anatomy and Reproductive Biology, University Hospital, Technical University, Aachen, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Perinatal Medicine |d Walter de Gruyter |g 32/2(2004-03-01), 137-143 |x 0300-5577 |q 32:2<137 |1 2004 |2 32 |o jpme | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 986 | |a SWISSBIB |b 378942409 | ||
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||