Oxytocic activity of thrombin: modulation of thrombin-induced gravid rat myometrial contractions by 5-hydroxytryptamine receptor antagonists
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| 024 | 7 | 0 | |a 10.1515/JPM.2004.023 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/JPM.2004.023 | ||
| 245 | 0 | 0 | |a Oxytocic activity of thrombin: modulation of thrombin-induced gravid rat myometrial contractions by 5-hydroxytryptamine receptor antagonists |h [Elektronische Daten] |c [A. Adebiyi, P. G. Adaikan, R. N. V. Prasad] |
| 520 | 3 | |a Background: Thrombin possesses potent oxytocic activity in vitro and in vivo. This activity has been proposed to play a role in post-parturitional uterine contractions and possibly, preterm birth related to intrauterine hemorrhage. Previous workers have demonstrated that cyclo-oxygenase pathway may not play a significant role in oxytocic activity of thrombin. However, the role of 5-hydroxytryptamine (a mediator of some of the biological activities of thrombin) in the oxytocic activity of thrombin is unknown. The present study therefore aimed to examine the possible involvement of 5-hydroxytryptamine in thrombin-induced myometrial contractions. Methods: Effect of 5-hydroxytryptamine receptor antagonists on thrombin-induced contractions of isolated gravid rat myometrium was studied using isolated tissue bath system. Results: Thrombin-induced myometrial contractions were significantly and concentration-dependently inhibited by ketanserin and methysergide. Furthermore, 12±2% increase in the force of contractions of gravid rat myometrium pre-contracted with 5-hydroxytryptamine (1 μM) was provoked by 1 U/ml of thrombin. Thrombin-induced augmentation of the uterine stimulating effect of 5-hydroxytryptamine was characterized by pronounced increase in the contractile tone. Conclusions: 5-hydroxytryptamine may possibly play a role in oxytocic activity of thrombin. Uterine hyperactivity associated with intrauterine hemorrhage could hence involve thrombin-induced 5-hydroxytryptamine production in the uterus. | |
| 540 | |a Copyright © 2004 by Walter de Gruyter GmbH & Co. KG | ||
| 690 | 7 | |a Human reproduction, growth & development |2 nationallicence | |
| 690 | 7 | |a Gynaecology & obstetrics |2 nationallicence | |
| 690 | 7 | |a Paediatric medicine |2 nationallicence | |
| 700 | 1 | |a Adebiyi |D A. |4 aut | |
| 700 | 1 | |a Adaikan |D P. G. |4 aut | |
| 700 | 1 | |a Prasad |D R. N. V. |4 aut | |
| 773 | 0 | |t Journal of Perinatal Medicine |d Walter de Gruyter |g 32/2(2004-03-15), 126-131 |x 0300-5577 |q 32:2<126 |1 2004 |2 32 |o jpme | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/JPM.2004.023 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/JPM.2004.023 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Adebiyi |D A. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Adaikan |D P. G. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Prasad |D R. N. V. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Perinatal Medicine |d Walter de Gruyter |g 32/2(2004-03-15), 126-131 |x 0300-5577 |q 32:2<126 |1 2004 |2 32 |o jpme | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||