caa a22 4500 386314489 CHVBK 20180307111601.0 cr unu---uuuuu 161130s1988 xx s 000 0 eng 10.1017/S0714980800007340 doi S0714980800007340 pii (NATIONALLICENCE)cambridge-10.1017/S0714980800007340 Harley Calvin B. McMaster University Biology and Evolution of Aging: Implications for Basic Gerontological Health Research [Elektronische Daten] [Calvin B. Harley] The maximum lifespan of different animal species is genetically determined. Many biochemical and physiological systems which influence longevity have apparently evolved to regulate growth and development in a way which maximizes fitness given the ecological niche and constraints on the species. The diversity of individual genetic effects on aging makes it unlikely that either extrinsic factors such as nutrition and medicine or genetic intervention will have dramatic effects on the maximum lifespan of a species, in spite of significant qualitative effects on individuals. However, understanding the fundamental genetic determinants of senescence may be of particular importance to the treatment and or prevention of age associated problems involving tissue degeneration and/or cancer. Considerable investment in basic biological research on both aging and developmental processes is needed before this understanding can be achieved. Copyright © Canadian Association on Gerontology 1988 genetic effects nationallicence longevity nationallicence research policy nationallicence Canadian Journal on Aging / La Revue canadienne du vieillissement Cambridge University Press 7/2(1988), 100-113 0714-9808 7:2<100 1988 7 CJG https://doi.org/10.1017/S0714980800007340 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0714980800007340 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Harley Calvin B. McMaster University NATIONALLICENCE 773 0- Canadian Journal on Aging / La Revue canadienne du vieillissement Cambridge University Press 7/2(1988), 100-113 0714-9808 7:2<100 1988 7 CJG CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge