caa a22 4500 386321035 CHVBK 20180307111626.0 cr unu---uuuuu 161130e198804 xx s 000 0 eng 10.1017/S0003356100042367 doi S0003356100042367 pii (NATIONALLICENCE)cambridge-10.1017/S0003356100042367 Growth promotion by oral administration of enkephalinase inhibitors (thiorphan and acetorphan) in rats and mice [Elektronische Daten] The effects of long-term oral administration of enkephalinase inhibitors (acetorphan and thiorphan) on food and water intake, live-weight gain and food conversion efficiency were investigated in growing rats and mice. In rats, daily drenching with acetorphan (an absorbable prodrug of thiorphan) at 1 mg/kg per day for 8 days did not alter food and water consumption but significantly increased live-weight gain (32·0 (s.d. 5·1) g for control rats v. 40·7 (s.d. 9·1) g for treated rats (P ≤ 0·05 U test) and improved food conversion efficiency (4·37 (s.d. 0·49) g food per g gain for control rats v. 3·70 (s.d. 0·67) g food per g gain for treated rats). In mice, lower doses (0·2 mg/kg per day) of thiorphan and acetorphan given in the drinking water similarly affected live-weight gain (7·7 (s.d. 0·9) g v. 6·0 (s.d. 1·6) g in 3-week-old mice receiving thiorphan and 2·6 (s.d. 0·4) g in 5-week-old mice receiving acetorphan) with a likely improvement in food conversion efficiency. These results suggest that oral administration of enkephalinase inhibitors may alter growth in rodents, probably by affecting the digestive process. Copyright © British Society of Animal Science 1988 Rivière P. J. M. Department of Pharmacology, Institut National Recherche Agronomique, 180 chemin de Tournefeuille, 31300 Toulouse, France Buéno L. Department of Pharmacology, Institut National Recherche Agronomique, 180 chemin de Tournefeuille, 31300 Toulouse, France Animal Production Cambridge University Press 46/2(1988-04), 291-295 0003-3561 46:2<291 1988 46 ASC https://doi.org/10.1017/S0003356100042367 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0003356100042367 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rivière P. J. M. Department of Pharmacology, Institut National Recherche Agronomique, 180 chemin de Tournefeuille, 31300 Toulouse, France NATIONALLICENCE 700 1- Buéno L. Department of Pharmacology, Institut National Recherche Agronomique, 180 chemin de Tournefeuille, 31300 Toulouse, France NATIONALLICENCE 773 0- Animal Production Cambridge University Press 46/2(1988-04), 291-295 0003-3561 46:2<291 1988 46 ASC CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge