caa a22 4500 386321752 CHVBK 20180307111628.0 cr unu---uuuuu 161130e198801 xx s 000 0 eng 10.1079/BJN19880009 doi S0007114588000108 pii (NATIONALLICENCE)cambridge-10.1079/BJN19880009 The influence of a high-protein, low-carbohydrate diet on bone development in the fetuses of rat dams with streptozotocin-induced diabetes [Elektronische Daten] 1. The purpose of the present study was to determine the effects of diet on the mandibles and growth centres of the long bones in the fetuses of diabetic rat dams given a normal diet compared with those given a high-protein, low-carbohydrate diet. 2. On the 9th day of gestation, the controls, groups 1 and 3, were injected with citrate buffer and given 200 and 600 g protein/kg diets respectively. Groups 2 and 4 were injected with 40 mg streptozotocin/kg body-weight and pair-fed with groups I and 3 respectively on the 200 and 600 g protein/kg diets. 3. On day 22, some dams were injected with either 45Ca or [14C]proline. Mandibles and long bones were removed and weighed and analysed for Ca content, 45Ca uptake, collagen and collagen synthesis. 4. The body-weights, and mandibular and long-bone weights of the fetuses in the diabetic 200 g protein/kg group were smaller than those of the non-diabetic 200 g protein/kg group, whereas those of the diabetic 600 g protein/kg group showed no difference from the non-diabetic 600 g protein/kg group. 5. The rate of collagen synthesis was higher in the fetuses of the diabetic 600 g protein/kg group than those of the non-diabetic group. Bones of the diabetic 200 g protein/kg group were lower in collagen content when compared with the non-diabetic group, whereas there was no difference between the diabetic and non-diabetic 600 g protein/kg groups. 6. Ca uptake and total Ca contents in the mandibles and long bones showed no difference between diabetic and non-diabetic groups fed on both diets. 7. A high-protein, low-carbohydrate diet appeared to have a certain beneficial effect on bone development of the growing fetuses from diabetic dams. Copyright © The Nutrition Society 1988 Harvey W. Keith Laboratory of Perinatal Nutrition and Metabolism, Department of Orthodontics, Louisiana State University Medical Center, New Orleans, LA 70119, USA Nakamoto Tetsuo Department of Physiology, Louisiana State University Medical Center, New Orleans, LA 70119, USA British Journal of Nutrition Cambridge University Press 59/1(1988-01), 57-62 0007-1145 59:1<57 1988 59 BJN https://doi.org/10.1079/BJN19880009 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1079/BJN19880009 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Harvey W. Keith Laboratory of Perinatal Nutrition and Metabolism, Department of Orthodontics, Louisiana State University Medical Center, New Orleans, LA 70119, USA NATIONALLICENCE 700 1- Nakamoto Tetsuo Department of Physiology, Louisiana State University Medical Center, New Orleans, LA 70119, USA NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 59/1(1988-01), 57-62 0007-1145 59:1<57 1988 59 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge