caa a22 4500 386321833 CHVBK 20180307111629.0 cr unu---uuuuu 161130e198801 xx s 000 0 eng 10.1079/BJN19880005 doi S0007114588000066 pii (NATIONALLICENCE)cambridge-10.1079/BJN19880005 Shennan D. B. Department of Human Anatomy, University of Oxford, South Parks Road, Oxford OX1 3QX Selenium (selenate) transport by human placental brush border membrane vesicles [Elektronische Daten] [D. B. Shennan] 1. Selenate uptake by human placental brush-border-membrane vesicles was studied in order to establish whether this anion shares a pathway with sulphate. 2. Selenate uptake was found to be saturable with respect to medium selenate and was inhibited by the anion exchange inhibitor 4,4′-diisothiocyano-stilbene-2,2′-disulphonate (DIDS). 3. Anions which have a similar tetrahedral shape to selenate, e.g. chromate, molybdate, tungstate and sulphate, were effective inhibitors of selenate uptake when added to the incubation medium. 4. Sulphate inhibited selenate influx in a dose-dependent fashion; moreover sulphate was found to be a competitive inhibitor of selenate uptake. 5. It is concluded that selenate and sulphate share a pathway for transport in the human placental microvillus membrane. Copyright © The Nutrition Society 1988 British Journal of Nutrition Cambridge University Press 59/1(1988-01), 13-19 0007-1145 59:1<13 1988 59 BJN https://doi.org/10.1079/BJN19880005 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1079/BJN19880005 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Shennan D. B. Department of Human Anatomy, University of Oxford, South Parks Road, Oxford OX1 3QX NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 59/1(1988-01), 13-19 0007-1145 59:1<13 1988 59 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge