caa a22 4500 386321914 CHVBK 20180307111629.0 cr unu---uuuuu 161130e198801 xx s 000 0 eng 10.1079/BJN19880011 doi S0007114588000121 pii (NATIONALLICENCE)cambridge-10.1079/BJN19880011 Haematological and tissue abnormalities in chicks caused by acute and subclinical folate deficiency [Elektronische Daten] 1. Haematological, histological and ultrastructural findings in young chicks fed on a purified diet severely deficient in folate are reported. 2. Growth of the birds was greatly depressed and they had a macrocytic anaemia. Other haematological changes included abnormal nuclear formations in erythrocytes, numerous mitoses and hypersegmented granulocytes. 3. Megaloblasts were observed in bone marrow and their fine structure is described for the first time in an avian species. 4. Morphological changes occurred also in the liver. The parenchyma had damaged sinusoidal endothelium, inflammatory cells and no glycogen. Mitochondria were damaged and many were associated with unusual crystalline structures. 5. Chickens fed on a semi-purified diet of low folate content showed no growth depression or clinical signs of deficiency but had abnormal haematological values and morphological changes that resembled those seen in birds fed on the purified diet. 6. These abnormalities responded to dietary supplements of pteroylmonoglutamic acid in a dose-related manner and may be useful in diagnosing subclinical folate deficiency. Copyright © The Nutrition Society 1988 Maxwell M. H. AFRC Institute for Grassland and Animal Production, Poultry Division, Roslin, Midlothian EH25 9PS Whitehead C. C. AFRC Institute for Grassland and Animal Production, Poultry Division, Roslin, Midlothian EH25 9PS Armstrong J. AFRC Institute for Grassland and Animal Production, Poultry Division, Roslin, Midlothian EH25 9PS British Journal of Nutrition Cambridge University Press 59/1(1988-01), 73-80 0007-1145 59:1<73 1988 59 BJN https://doi.org/10.1079/BJN19880011 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1079/BJN19880011 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maxwell M. H. AFRC Institute for Grassland and Animal Production, Poultry Division, Roslin, Midlothian EH25 9PS NATIONALLICENCE 700 1- Whitehead C. C. AFRC Institute for Grassland and Animal Production, Poultry Division, Roslin, Midlothian EH25 9PS NATIONALLICENCE 700 1- Armstrong J. AFRC Institute for Grassland and Animal Production, Poultry Division, Roslin, Midlothian EH25 9PS NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 59/1(1988-01), 73-80 0007-1145 59:1<73 1988 59 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge