caa a22 4500 386321930 CHVBK 20180307111629.0 cr unu---uuuuu 161130e198801 xx s 000 0 eng 10.1079/BJN19880018 doi S0007114588000194 pii (NATIONALLICENCE)cambridge-10.1079/BJN19880018 Effect of experimental zinc deficiency and repletion on some immunological variables in guinea-pigs [Elektronische Daten] 1. Cellular and humoral immune responses were studied in guinea-pigs fed on zinc-deficient (ZnD), Zn-adequate (control) and Zn-replete diets containing 1·25, 50 and 100 mg Zn/kg diet respectively. 2. It was found that the ZnD guinea-pigs had significantly decreased ability to elicit delayed-type hypersensitivity (DTH) response against sheep erythrocytes as compared with controls on the 9th day of immunization. This was further substantiated by histological examination of DTH-positive skin sections. 3. A significant reduction in direct splenic plaque-forming-cell response and haemagglutinating-antibody titre was also observed in ZnD guinea-pigs. 4. Serum electrophoretic studies revealed a highly disordered protein profile with a significantly depressed value for γ-globulin. 5. Zn repletion of the previously ZnD group resulted in marked, though incomplete, restoration of immunological responses. Copyright © The Nutrition Society 1988 Verma P. C. Department of Veterinary Pathology, College of Veterinary Sciences, Haryana Agricultural University, Hisar-125 004, India Gupta R. P. Department of Veterinary Pathology, College of Veterinary Sciences, Haryana Agricultural University, Hisar-125 004, India Sadana J. R. Department of Veterinary Pathology, College of Veterinary Sciences, Haryana Agricultural University, Hisar-125 004, India Paul Gupta R. K. Department of Veterinary Pathology, College of Veterinary Sciences, Haryana Agricultural University, Hisar-125 004, India British Journal of Nutrition Cambridge University Press 59/1(1988-01), 149-154 0007-1145 59:1<149 1988 59 BJN https://doi.org/10.1079/BJN19880018 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1079/BJN19880018 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Verma P. C. Department of Veterinary Pathology, College of Veterinary Sciences, Haryana Agricultural University, Hisar-125 004, India NATIONALLICENCE 700 1- Gupta R. P. Department of Veterinary Pathology, College of Veterinary Sciences, Haryana Agricultural University, Hisar-125 004, India NATIONALLICENCE 700 1- Sadana J. R. Department of Veterinary Pathology, College of Veterinary Sciences, Haryana Agricultural University, Hisar-125 004, India NATIONALLICENCE 700 1- Paul Gupta R. K. Department of Veterinary Pathology, College of Veterinary Sciences, Haryana Agricultural University, Hisar-125 004, India NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 59/1(1988-01), 149-154 0007-1145 59:1<149 1988 59 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge