caa a22 4500 386321949 CHVBK 20180307111629.0 cr unu---uuuuu 161130e198801 xx s 000 0 eng 10.1079/BJN19880008 doi S0007114588000091 pii (NATIONALLICENCE)cambridge-10.1079/BJN19880008 The effect of Gypsophila saponins in the diet on mineral status and plasma cholesterol concentration in the rat [Elektronische Daten] 1. Immature, male Wistar rats were allocated to one of six groups and caged individually. The first group was given a semi-synthetic diet containing 38 mg iron and 55 mg zinc/kg (basal group). The second and third groups were given a diet containing 10 mg Zn and 12 mg Fe/kg respectively (low-Zn and low-Fe groups). Groups four, five and six were given similar diets containing 20 g Gypsophila saponins/kg. After 21 d the Fe and Zn status of the rats was estimated and plasma cholesterol concentration determined. 2. Measurements of whole blood haemoglobin concentration, packed cell volume and liver Fe stores indicated that rats in the basal + saponin and low-Fe + saponin groups had a significantly reduced Fe status when compared with their controls. Rats in the low-Zn + saponin group also showed a trend toward reduced Fe stores. 3. Zn status, as judged by femur Zn concentration, was not adversely affected by the inclusion of Gypsophila saponins in the diet. 4. Consumption of the saponins resulted in a significant reduction in blood cholesterol concentration, with rats in both the low-Fe groups having significantly lower concentrations than their basal and low-Zn counterparts. 5. In view of suggestions that the consumption of saponins should be encouraged because of their ability to lower blood cholesterol, possible effects on Fe metabolism should be investigated further, particularly with respect to the levels and sources of saponin in the human diet. Copyright © The Nutrition Society 1988 Southon Susan AFRC Institute of Food Research, Norwich Laboratory, Colney Lane, Norwich NR4 7UA Johnson I. T. AFRC Institute of Food Research, Norwich Laboratory, Colney Lane, Norwich NR4 7UA Gee Jennifer M. AFRC Institute of Food Research, Norwich Laboratory, Colney Lane, Norwich NR4 7UA Price K. R. AFRC Institute of Food Research, Norwich Laboratory, Colney Lane, Norwich NR4 7UA British Journal of Nutrition Cambridge University Press 59/1(1988-01), 49-55 0007-1145 59:1<49 1988 59 BJN https://doi.org/10.1079/BJN19880008 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1079/BJN19880008 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Southon Susan AFRC Institute of Food Research, Norwich Laboratory, Colney Lane, Norwich NR4 7UA NATIONALLICENCE 700 1- Johnson I. T. AFRC Institute of Food Research, Norwich Laboratory, Colney Lane, Norwich NR4 7UA NATIONALLICENCE 700 1- Gee Jennifer M. AFRC Institute of Food Research, Norwich Laboratory, Colney Lane, Norwich NR4 7UA NATIONALLICENCE 700 1- Price K. R. AFRC Institute of Food Research, Norwich Laboratory, Colney Lane, Norwich NR4 7UA NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 59/1(1988-01), 49-55 0007-1145 59:1<49 1988 59 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge