caa a22 4500 386321965 CHVBK 20180307111629.0 cr unu---uuuuu 161130e198805 xx s 000 0 eng 10.1079/BJN19830079 doi S0007114588000583 pii (NATIONALLICENCE)cambridge-10.1079/BJN19830079 The phosphorylation state of casein and the species-dependency of its hypercholesterolaemic effect [Elektronische Daten] 1. The present study concerns the question whether the hypercholesterolaemic effect of casein, a phosphorylated protein, is modified in species differing both in glycine-taurine conjugation of bile acids and in intestinal alkaline phosphatase (EC 3.1.3.1). 2. Since these two variables are entirely different in rabbits and rats, identical (cholesterol-free) semi-purified diets containing either casein or soya-bean protein were given to both species. 3. In rabbits casein, as compared with soya-bean protein, did not affect calcium absorption but immediately increased phosphate absorption and decreased faecal excretion of bile acids. These effects preceded the accumulation of apo B-cholesterol in serum, which indicates a cause-and-effect relation. 4. In contrast, none of these casein-specific effects were observed in rats. 5. These results suggest that the hypercholesterolaemic potential of casein is expressed mainly in species (like the rabbit) with a low activity of intestinal phosphatase and with a high glycine conjugation of bile acids. This might explain why species (like rat and man) are rather insensitive to dietary casein. Copyright © The Nutrition Society 1988 Van Der Meer Roelof Department of Nutrition, Netherlands Institute for Dairy Research, PO Box 20, 6710 BA Ede, The Netherlands De Vries Hielke T. Department of Nutrition, Netherlands Institute for Dairy Research, PO Box 20, 6710 BA Ede, The Netherlands Van Tintelen Gerrit Department of Nutrition, Netherlands Institute for Dairy Research, PO Box 20, 6710 BA Ede, The Netherlands British Journal of Nutrition Cambridge University Press 59/3(1988-05), 467-473 0007-1145 59:3<467 1988 59 BJN https://doi.org/10.1079/BJN19830079 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1079/BJN19830079 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Van Der Meer Roelof Department of Nutrition, Netherlands Institute for Dairy Research, PO Box 20, 6710 BA Ede, The Netherlands NATIONALLICENCE 700 1- De Vries Hielke T. Department of Nutrition, Netherlands Institute for Dairy Research, PO Box 20, 6710 BA Ede, The Netherlands NATIONALLICENCE 700 1- Van Tintelen Gerrit Department of Nutrition, Netherlands Institute for Dairy Research, PO Box 20, 6710 BA Ede, The Netherlands NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 59/3(1988-05), 467-473 0007-1145 59:3<467 1988 59 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge