caa a22 4500 386322147 CHVBK 20180307111630.0 cr unu---uuuuu 161130e198807 xx s 000 0 eng 10.1079/BJN19880077 doi S0007114588000789 pii (NATIONALLICENCE)cambridge-10.1079/BJN19880077 Effect of the duration of malnutrition and of nutritional rehabilitation on blood glucose homeostasis and pancreatic hormones in rats [Elektronische Daten] 1. To study the efficiency of rehabilitation after different periods of protein-energy malnutrition, we used as a model preweaning malnourished rats. After weaning, male Wistar rats were fed on a protein-deficient diet (50 g casein/kg) ad lib. for the whole study (DR group) or rehabilitated with normal diet (180 g casein/kg; RR group) from weaning, week 0, or weeks 1, 3, 5, 8 and 16 thereafter. 2. Twelve animals from the DR group were killed at the beginning of each rehabilitation period. The twelve rehabilitated rats were killed after 2 weeks. Body-weight and epididymal adipose tissue weight, blood glucose, plasma immunoreactive insulin (IRI) and immunoreactive glucagon (IRG), and pancreatic contents of IRI and IRG were determined. 3. Food intake of RR rats rose significantly except during the last period where body-weight increased less than that during the previous periods. Fat-pad weights increased in the same manner in DR and RR groups. 4. Blood glucose fell and plasma IRG rose significantly without any change in plasma IRI after each rehabilitation period, except during the last period where blood glucose concentrations became stable. Pancreatic IRG and IRI showed the same type of response to those of the plasma. 5. All short-term rehabilitation periods were similarly efficient at producing catch-up growth. High insulin sensitivity of target cells was responsible for good recovery except after long-term malnutrition. Copyright © The Nutrition Society 1988 Dollet Jean-Marc Unité de Recherches sur les Mécanismes de Régulation du Comportement Alimentaire, INSERM U 308, 38 rue Lionnois, 54000 Nancy, France Beck Bernard Unité de Recherches sur les Mécanismes de Régulation du Comportement Alimentaire, INSERM U 308, 38 rue Lionnois, 54000 Nancy, France Max Jean-Pierre Unité de Recherches sur les Mécanismes de Régulation du Comportement Alimentaire, INSERM U 308, 38 rue Lionnois, 54000 Nancy, France British Journal of Nutrition Cambridge University Press 60/1(1988-07), 69-76 0007-1145 60:1<69 1988 60 BJN https://doi.org/10.1079/BJN19880077 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1079/BJN19880077 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dollet Jean-Marc Unité de Recherches sur les Mécanismes de Régulation du Comportement Alimentaire, INSERM U 308, 38 rue Lionnois, 54000 Nancy, France NATIONALLICENCE 700 1- Beck Bernard Unité de Recherches sur les Mécanismes de Régulation du Comportement Alimentaire, INSERM U 308, 38 rue Lionnois, 54000 Nancy, France NATIONALLICENCE 700 1- Max Jean-Pierre Unité de Recherches sur les Mécanismes de Régulation du Comportement Alimentaire, INSERM U 308, 38 rue Lionnois, 54000 Nancy, France NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 60/1(1988-07), 69-76 0007-1145 60:1<69 1988 60 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge