caa a22 4500 38632235X CHVBK 20180307111631.0 cr unu---uuuuu 161130e198805 xx s 000 0 eng 10.1079/BJN19880054 doi S000711458800056X pii (NATIONALLICENCE)cambridge-10.1079/BJN19880054 Glutathione deficiency and peripheral metabolism of thyroid hormones during dietary cysteine deprivation in rats [Elektronische Daten] 1. For a period of 24 d, young rats received a diet containing 120 g casein/kg or the same basic diet supplemented with 1·93 g cysteine/kg. 2. The thyroxine (T4) turnover was decreased in rats receiving the cysteine-deficient diet compared with that of rats on the supplemented diet. Moreover, the extrathyroidal T4 pool and T4 disposal rate decreased. 3. Cysteine deprivation also decreased the peripheral metabolism of 3,5,3'-triiodothyronine (T3). The T3 distribution space, extrathyroidal pool of T3 and T3 disposal rate were diminished. 4. In vitro, deiodination of T4 in liver homogenate assayed with endogenous glutathione (GSH) demonstrated decreased T3 production rates in the case of cysteine deficiency. This difference was minimized by the addition of GSH in amounts sufficient to saturate the reaction kinetics. In the light of this finding, GSH is probably involved in the promotion of certain thyroidal problems induced by a cysteine-deficient diet. Copyright © The Nutrition Society 1988 Suberville C. Laboratoire Physiologie de la Nutrition, Département Alimentation et Nutrition, Université de Bordeaux I, avenue des Facultés, 33405 Talence-Cédex, France Higueret P. Laboratoire Physiologie de la Nutrition, Département Alimentation et Nutrition, Université de Bordeaux I, avenue des Facultés, 33405 Talence-Cédex, France Taruoura D. Laboratoire Physiologie de la Nutrition, Département Alimentation et Nutrition, Université de Bordeaux I, avenue des Facultés, 33405 Talence-Cédex, France Garcin H. Laboratoire Physiologie de la Nutrition, Département Alimentation et Nutrition, Université de Bordeaux I, avenue des Facultés, 33405 Talence-Cédex, France Higueret D. Laboratoire Biochimie Médicale, Hôpital Pellegrin, Place Raba Léon, 33000 Bordeaux, France British Journal of Nutrition Cambridge University Press 59/3(1988-05), 451-456 0007-1145 59:3<451 1988 59 BJN https://doi.org/10.1079/BJN19880054 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1079/BJN19880054 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Suberville C. Laboratoire Physiologie de la Nutrition, Département Alimentation et Nutrition, Université de Bordeaux I, avenue des Facultés, 33405 Talence-Cédex, France NATIONALLICENCE 700 1- Higueret P. Laboratoire Physiologie de la Nutrition, Département Alimentation et Nutrition, Université de Bordeaux I, avenue des Facultés, 33405 Talence-Cédex, France NATIONALLICENCE 700 1- Taruoura D. Laboratoire Physiologie de la Nutrition, Département Alimentation et Nutrition, Université de Bordeaux I, avenue des Facultés, 33405 Talence-Cédex, France NATIONALLICENCE 700 1- Garcin H. Laboratoire Physiologie de la Nutrition, Département Alimentation et Nutrition, Université de Bordeaux I, avenue des Facultés, 33405 Talence-Cédex, France NATIONALLICENCE 700 1- Higueret D. Laboratoire Biochimie Médicale, Hôpital Pellegrin, Place Raba Léon, 33000 Bordeaux, France NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 59/3(1988-05), 451-456 0007-1145 59:3<451 1988 59 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge