caa a22 4500 386322414 CHVBK 20180307111631.0 cr unu---uuuuu 161130e198805 xx s 000 0 eng 10.1079/BJN19880052 doi S0007114588000546 pii (NATIONALLICENCE)cambridge-10.1079/BJN19880052 A possible relation between dietary zinc and cAMP in the regulation of tumour cell proliferation in the rat [Elektronische Daten] 1. The possibility of an effect of zinc on the rate of tumour cell division, mediated through a regulation of cellular cAMP concentration, was investigated in the present study in rats. 2. Dietary Zn deficiency (< 1·5 mg Zn/kg) but not Zn excess (500 mg Zn/kg) resulted in an increased cAMP concentration in transplanted hepatoma cells. Neither treatment had any effect on the cAMP concentration in regenerating liver or normal resting liver. Both the deficient and excess Zn diets resulted in a small reduction in tumour growth (not statistically significant). 3. The results seem to indicate that the relation investigated in the present study does not apply in the cell line used. Copyright © The Nutrition Society 1988 Skeef Noel S. Department of Chemistry and Biochemistry, Rhodes University, Grahamstown 6140, South Africa Duncan John R. Department of Chemistry and Biochemistry, Rhodes University, Grahamstown 6140, South Africa British Journal of Nutrition Cambridge University Press 59/3(1988-05), 437-442 0007-1145 59:3<437 1988 59 BJN https://doi.org/10.1079/BJN19880052 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1079/BJN19880052 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Skeef Noel S. Department of Chemistry and Biochemistry, Rhodes University, Grahamstown 6140, South Africa NATIONALLICENCE 700 1- Duncan John R. Department of Chemistry and Biochemistry, Rhodes University, Grahamstown 6140, South Africa NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 59/3(1988-05), 437-442 0007-1145 59:3<437 1988 59 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge