caa a22 4500 386322430 CHVBK 20180307111631.0 cr unu---uuuuu 161130e198809 xx s 000 0 eng 10.1079/BJN19880093 doi S0007114588000947 pii (NATIONALLICENCE)cambridge-10.1079/BJN19880093 Effects of dietary-fish-oil feeding on muscle growth and damage in the rat [Elektronische Daten] 1. Giving diets containing 100 g fully-refined, non-hydrogenated fish oil/kg to rats caused substantial modification of skeletal-muscle-membrane fatty acid composition compared with control animals fed on an equivalent diet containing 100 g maize oil/kg. 2. Total muscle arachidonic acid (20:4ω6) was reduced from 138 (sd 25) mg/g total fatty acids to 15 (sd 2) mg/ g and phospholipid arachidonic acid content showed equivalent changes. 3. Reduction in muscle arachidonic acid content had no influence on the growth of individual muscles. 4. Variation in muscle fatty acid composition exacerbated the response of muscle to calcium-induced damage assessed by efflux of intracellular creatine kinase (EC 2.7.3.2). 5. It is concluded that metabolites of arachidonic acid are unlikely to be primary controlling factors of muscle growth or specific mediators of muscle sarcolemmal damage leading to enzyme efflux. Copyright © The Nutrition Society 1988 Jackson M. J. Department of Medicine, University of Liverpool, PO Box 147, Liverpool L69 3BX Roberts J. Department of Medicine, University of Liverpool, PO Box 147, Liverpool L69 3BX Edwards R. H. T. Department of Medicine, University of Liverpool, PO Box 147, Liverpool L69 3BX British Journal of Nutrition Cambridge University Press 60/2(1988-09), 217-224 0007-1145 60:2<217 1988 60 BJN https://doi.org/10.1079/BJN19880093 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1079/BJN19880093 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jackson M. J. Department of Medicine, University of Liverpool, PO Box 147, Liverpool L69 3BX NATIONALLICENCE 700 1- Roberts J. Department of Medicine, University of Liverpool, PO Box 147, Liverpool L69 3BX NATIONALLICENCE 700 1- Edwards R. H. T. Department of Medicine, University of Liverpool, PO Box 147, Liverpool L69 3BX NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 60/2(1988-09), 217-224 0007-1145 60:2<217 1988 60 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge