caa a22 4500 386322716 CHVBK 20180307111632.0 cr unu---uuuuu 161130e198803 xx s 000 0 eng 10.1079/BJN19880036 doi S0007114588000376 pii (NATIONALLICENCE)cambridge-10.1079/BJN19880036 Studies of the changes in systemic copper metabolism and excretion produced by the intravenous administration of trithiomolybdate in sheep [Elektronische Daten] 1. The effects of intravenous trithiomolybdate administration on the fate of 64Cu and on stable Cu metabolism were examined in sheep held in metabolism cages and fed on a low-Cu diet supplying 2·95 mg Cu/animal per d. 2. In Expt 1 the injection of trithiomolybdate, 30 mg molybdenum/sheep per d for 5 d, greatly increased plasma Cu levels and more than doubled the faecal Cu excretion. Urinary Cu excretion was unaffected. The disappearance from plasma of 64Cu injected during the trithiomolybdate administration was slowed although faecal 64Cu excretion was increased more than threefold. 3. In Expt 2 trithiomolybdate, 10 and 30 mg Mo/sheep per d for 3 d, was administered 22 h after the injection of 64Cu. Radioactivity reappeared immediately in plasma and faecal 64Cu excretion was increased. 4. In both experiments the 64Cu and the increased stable Cu in plasma were associated with albumin. 5. The experiments explain the effectiveness of thiomolybdates as ‘decoppering' agents and provide a model for some of the systemic effects seen in ruminants exposed to increased dietary Mo. The experiments support the view that the thiomolybdates, by causing the appearance of new ligands, alter the distribution of Cu in tissues and cause an overall depletion. Copyright © The Nutrition Society 1988 Mason J. Biochemistry Department, Trinity College, Dublin 2, Irish Republic Lamand M. Laboratoire des Maladies Nutritionnelles, INRA, CRZV de Theix 63122, Ceyrat, France Tressol J. C. Laboratoire des Maladies Nutritionnelles, INRA, CRZV de Theix 63122, Ceyrat, France Mulryan G. Biochemistry Department, Trinity College, Dublin 2, Irish Republic British Journal of Nutrition Cambridge University Press 59/2(1988-03), 289-300 0007-1145 59:2<289 1988 59 BJN https://doi.org/10.1079/BJN19880036 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1079/BJN19880036 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mason J. Biochemistry Department, Trinity College, Dublin 2, Irish Republic NATIONALLICENCE 700 1- Lamand M. Laboratoire des Maladies Nutritionnelles, INRA, CRZV de Theix 63122, Ceyrat, France NATIONALLICENCE 700 1- Tressol J. C. Laboratoire des Maladies Nutritionnelles, INRA, CRZV de Theix 63122, Ceyrat, France NATIONALLICENCE 700 1- Mulryan G. Biochemistry Department, Trinity College, Dublin 2, Irish Republic NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 59/2(1988-03), 289-300 0007-1145 59:2<289 1988 59 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge