caa a22 4500 386322767 CHVBK 20180307111632.0 cr unu---uuuuu 161130e198803 xx s 000 0 eng 10.1079/BJN19880031 doi S0007114588000327 pii (NATIONALLICENCE)cambridge-10.1079/BJN19880031 Effect of moderate magnesium deficiency on serum lipids, blood pressure and cardiovascular reactivity in normotensive rats [Elektronische Daten] 1. Weanling Wistar rats were pair fed for 10 weeks on a purified diet containing either normal or suboptimal quantities of magnesium (960 or 80 mg/kg respectively). 2. At week 2, hypomagnesaemia was accompanied by hypertriglyceridaemia, an increase in plasma cholesterol and a decrease in high-density-lipoprotein-cholesterol in animals fed on the Mg-deficient diet. At week 10, the increase in triglycerides observed in Mg-deficient animals was less marked while the increase in total cholesterol was more important. 3. During the whole experimental period, Mg-deficient animals never showed hypertension. At week 2, mean arterial blood pressure was significantly lower in Mg-deficient rats than in their respective controls, while heart rate was significantly increased. However, hypotension accompanied by tachycardia was a transitory phenomenon which appeared only in the early phase of deficiency. 4. Vascular reactivity was studied in vagotomized anaesthetized rats after ganglionic blockade with pentolinium and atropine sulphate. The reactivity to noradrenaline was significantly higher in Mg-deficient rats compared with pair-fed controls after 2 weeks on the experimental diet. Copyright © The Nutrition Society 1988 Luthringer Catherine Institut National de la Recherche Agronomique, Theix 63122 Ceyrat, France Rayssiguier Yves Institut National de la Recherche Agronomique, Theix 63122 Ceyrat, France Gueux Elyett Institut National de la Recherche Agronomique, Theix 63122 Ceyrat, France Berthelot Alain Institut National de la Recherche Agronomique, Theix 63122 Ceyrat, France British Journal of Nutrition Cambridge University Press 59/2(1988-03), 243-250 0007-1145 59:2<243 1988 59 BJN https://doi.org/10.1079/BJN19880031 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1079/BJN19880031 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Luthringer Catherine Institut National de la Recherche Agronomique, Theix 63122 Ceyrat, France NATIONALLICENCE 700 1- Rayssiguier Yves Institut National de la Recherche Agronomique, Theix 63122 Ceyrat, France NATIONALLICENCE 700 1- Gueux Elyett Institut National de la Recherche Agronomique, Theix 63122 Ceyrat, France NATIONALLICENCE 700 1- Berthelot Alain Institut National de la Recherche Agronomique, Theix 63122 Ceyrat, France NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 59/2(1988-03), 243-250 0007-1145 59:2<243 1988 59 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge