caa a22 4500 386322783 CHVBK 20180307111632.0 cr unu---uuuuu 161130e198803 xx s 000 0 eng 10.1079/BJN19880029 doi S0007114588000303 pii (NATIONALLICENCE)cambridge-10.1079/BJN19880029 The effect of guar gum on the distribution of a radiolabelled meal in the gastrointestinal tract of the rat [Elektronische Daten] 1. The effect of addition of guar gum (5 and 10 g/l) to a radiolabelled, homogenized, baked-bean test meal on the distribution of that meal in the gastrointestinal tract was investigated in groups of male rats killed at 25, 50, 100, 200, 300 and 400 min after gavage. 2. Addition of 5 and 10 g guar gum/l significantly increased the proportion of the meal remaining in the stomach at 25 and 50 min after gavage (P <0·01). 3. The heads of the control meal and meals containing guar gum reached the distal small intestine within 25 min after gavage but radioactivity was not observed in the caecum until 100 min after administration of each of the meals. Addition of guar gum (5 and 10 g/l) delayed caecal filling even though the head of each meal reached the caecum at the same time after gavage. 4. The geometric centres of guar-gum-containing meals were proximal to that of the control meal at all times after gavage. 5. The observed delay in the passage of a guar-gum-containing meal through the stomach and small intestine is probably due to the viscous nature of the meal resisting the propulsive and mixing effects of the gastrointestinal contractions, thereby reducing access of the glucose to the absorptive epithelium. This could contribute to the observed reductions in postprandial glycaemia seen in previous studies after incorporating guar gum into a meal. Copyright © The Nutrition Society 1988 Brown Nicola J. Sub-Department of Human Gastrointestinal Physiology and Nutrition, Physiology Department, University of Sheffield, Western Bank, Sheffield SIO 2TN Worlding Jane Sub-Department of Human Gastrointestinal Physiology and Nutrition, Physiology Department, University of Sheffield, Western Bank, Sheffield SIO 2TN Rumsey R. D. E. Sub-Department of Human Gastrointestinal Physiology and Nutrition, Physiology Department, University of Sheffield, Western Bank, Sheffield SIO 2TN Read N. W. Sub-Department of Human Gastrointestinal Physiology and Nutrition, Physiology Department, University of Sheffield, Western Bank, Sheffield SIO 2TN British Journal of Nutrition Cambridge University Press 59/2(1988-03), 223-231 0007-1145 59:2<223 1988 59 BJN https://doi.org/10.1079/BJN19880029 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1079/BJN19880029 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brown Nicola J. Sub-Department of Human Gastrointestinal Physiology and Nutrition, Physiology Department, University of Sheffield, Western Bank, Sheffield SIO 2TN NATIONALLICENCE 700 1- Worlding Jane Sub-Department of Human Gastrointestinal Physiology and Nutrition, Physiology Department, University of Sheffield, Western Bank, Sheffield SIO 2TN NATIONALLICENCE 700 1- Rumsey R. D. E. Sub-Department of Human Gastrointestinal Physiology and Nutrition, Physiology Department, University of Sheffield, Western Bank, Sheffield SIO 2TN NATIONALLICENCE 700 1- Read N. W. Sub-Department of Human Gastrointestinal Physiology and Nutrition, Physiology Department, University of Sheffield, Western Bank, Sheffield SIO 2TN NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 59/2(1988-03), 223-231 0007-1145 59:2<223 1988 59 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge