caa a22 4500 386322805 CHVBK 20180307111632.0 cr unu---uuuuu 161130e198803 xx s 000 0 eng 10.1079/BJN19880030 doi S0007114588000315 pii (NATIONALLICENCE)cambridge-10.1079/BJN19880030 Interaction of dietary carbohydrate and fat in the regulation of hepatic and extrahepatic lipogenesis in the rat [Elektronische Daten] 1. In order to examine the interaction of dietary fat and carbohydrate in the regulation of lipid metabolism, we have studied hepatic and extrahepatic lipogenesis, and adipose tissue lipoprotein lipase (EC 3.1.1.34) in rats fed on one of the following diets: a fructose-based diet containing 0 (F0) or 150 g maize oil (F15)/kg, or a glucose based diet containing 0 (G0) or 150 g maize oil (G15)/kg. 2. The rats were meal-fed on the diets for 2 weeks after which the activities of a number of hepatic ‘lipogenic' enzymes were measured and the activity of epididymal-fat-pad lipoprotein lipase. The activities of the lipogenic enzymes were: F0 > G0 > G15 > F15. Lipoprotein lipase activity was F0 = G0 = F15 = G15. The percentage of total body fatty acid synthesis which occurred in the liver was F0 > G0 > F15 > G15. 3. We conclude that fructose-induced hypertriglyceridaemia is primarily a result of the increased hepatic synthesis rather than decreased adipose-tissue lipoprotein lipase activity. Copyright © The Nutrition Society 1988 Herzberg Gene R. Biochemistry Department, Memorial University of Newfoundland, St John's, Newfoundland AIB 3X9, Canada Rogerson Maria Biochemistry Department, Memorial University of Newfoundland, St John's, Newfoundland AIB 3X9, Canada British Journal of Nutrition Cambridge University Press 59/2(1988-03), 233-241 0007-1145 59:2<233 1988 59 BJN https://doi.org/10.1079/BJN19880030 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1079/BJN19880030 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Herzberg Gene R. Biochemistry Department, Memorial University of Newfoundland, St John's, Newfoundland AIB 3X9, Canada NATIONALLICENCE 700 1- Rogerson Maria Biochemistry Department, Memorial University of Newfoundland, St John's, Newfoundland AIB 3X9, Canada NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 59/2(1988-03), 233-241 0007-1145 59:2<233 1988 59 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge