caa a22 4500 38632283X CHVBK 20180307111632.0 cr unu---uuuuu 161130e198811 xx s 000 0 eng 10.1079/BJN19880121 doi S0007114588001230 pii (NATIONALLICENCE)cambridge-10.1079/BJN19880121 Growth, ascorbic acid and iron contents of tissues of young guinea-pigs whose dams received high or low levels of dietary ascorbic acid or Fe during pregnancy and suckling [Elektronische Daten] 1. Guinea-pig dams were fed on purified diets containing high (5 g/kg diet plus 1 g/l drinking water) or moderate (0.5 g/kg diet) levels of ascorbic acid, in combination with high (1 g/kg diet) or moderate (0.043 g/kg diet) levels of iron, during pregnancy and suckling. Their offsprings' diets contained 0.1 g ascorbic acid/kg and 0.04 g Fe/kg. 2. High ascorbic acid intake clearly enhanced both tissue ascorbate and Fe storage in the dams, and high Fe intake increased both the dams' and the pups' tissue Fe stores. 3. In the animals receiving high Fe intake, a co-existing high ascorbate intake by the dams reduced the growth rate of the offspring, but only during the early stages of development, not during the later stages of post-weaning growth. All the pups' tissue ascorbate levels fell after weaning, but those born of the dams receiving the high ascorbic acid diets did not fall to levels lower than those of the other pups. 4. Thus, although certain disadvantages to the offspring resulting from very-high ascorbic acid intake by pregnant guinea-pig dams were detected, these did not include permanently increased ascorbate requirements, and hence a progression to scurvy as the pups grew and matured. Copyright © The Nutrition Society 1988 Bates C. J. MRC Dunn Nutritional Laboratory, Downham's Lane, Milton Road, Cambridge CB4 IXJ Cowen T. D. MRC Dunn Nutritional Laboratory, Downham's Lane, Milton Road, Cambridge CB4 IXJ Tsuchiya Harumi MRC Dunn Nutritional Laboratory, Downham's Lane, Milton Road, Cambridge CB4 IXJ British Journal of Nutrition Cambridge University Press 60/3(1988-11), 487-497 0007-1145 60:3<487 1988 60 BJN https://doi.org/10.1079/BJN19880121 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1079/BJN19880121 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bates C. J. MRC Dunn Nutritional Laboratory, Downham's Lane, Milton Road, Cambridge CB4 IXJ NATIONALLICENCE 700 1- Cowen T. D. MRC Dunn Nutritional Laboratory, Downham's Lane, Milton Road, Cambridge CB4 IXJ NATIONALLICENCE 700 1- Tsuchiya Harumi MRC Dunn Nutritional Laboratory, Downham's Lane, Milton Road, Cambridge CB4 IXJ NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 60/3(1988-11), 487-497 0007-1145 60:3<487 1988 60 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge