caa a22 4500 386322848 CHVBK 20180307111633.0 cr unu---uuuuu 161130e198811 xx s 000 0 eng 10.1079/BJN19880128 doi S0007114588001308 pii (NATIONALLICENCE)cambridge-10.1079/BJN19880128 The effects of dietary fat content on the growth and body composition of lean and genetically obese Zucker rats adrenalectomized before weaning [Elektronische Daten] 1. Lean (Fa/-) and obese (fa/fa) Zucker rats were adrenalectomized or sham-operated at 18 d of age (3 d before weaning). After weaning the rats were fed ad lib. on semi-synthetic diets containing either a low (8 g/kg) or a high (178 g/kg) proportion of fat. Other groups of sham-operated rats were given the same amount eaten by adrenalectomized animals (restricted intake). Rats were killed at 40 d of age. 2. Adrenalectomy reduced the body lipid content of lean and obese rats compared with intact animals fed ad lib. or given a restricted intake. Adrenalectomized obese rats contained more body lipid than intact or adrenalectomized lean rats. 3. Sham-operated obese rats given a restricted intake had less body protein than similarly treated lean animals and this phenotypic difference was abolished by adrenalectomy. 4. There were no effects of diet on growth or body composition of intact or adrenalectomized rats. 5. It is concluded that preweaning adrenalectomy prevented development of the obese phenotype when rats were fed on either diet. Comparison of these results with a previous study, in which adrenalectomized Zucker rats were fed on a stock diet (Fletcher, 1986b), showed, however, that feeding either of the semi-synthetic diets caused greater deposition of body lipid in obese rats. Copyright © The Nutrition Society 1988 Fletcher J. M. Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB McKenzie N. Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB British Journal of Nutrition Cambridge University Press 60/3(1988-11), 563-569 0007-1145 60:3<563 1988 60 BJN https://doi.org/10.1079/BJN19880128 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1079/BJN19880128 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fletcher J. M. Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB NATIONALLICENCE 700 1- McKenzie N. Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 60/3(1988-11), 563-569 0007-1145 60:3<563 1988 60 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge