caa a22 4500 386334153 CHVBK 20180307111727.0 cr unu---uuuuu 161130e198903 xx s 000 0 eng 10.1017/S0790966700015676 doi S0790966700015676 pii (NATIONALLICENCE)cambridge-10.1017/S0790966700015676 Mander A.J. University Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF Prediction of Rapid Relapse Following Lithium Discontinuation [Elektronische Daten] [A.J. Mander] All twenty-nine bipolar 1 patents who satisfied DSM-111 criteria following their first hospitalisation for mania and subsequently discontinued their prophylactic lithium after a mean of 29 ± 21 months were studied. Patients were classified into poor prognosis (relapsed within 3 months of discontinuation, n = 8) and good prognosis groups (relapsed after 3 months or did not relapse, n = 21). Poor prognosis patients were more likely to have been prescribed additional psychotropic medication in the previous year (P = 0.026) and had higher serum lithium levels immediately prior to lithium discontinuation (P = 0.0043). Recent additional psychotropic medication may indicate that the patient is at an increased risk of early relapse if lithium prophylaxis is being stopped for any reason. The increased risk for those patients with higher lithium levels suggest that gradual phased reductions would be prudent. Copyright © Cambridge University Press 1989 Lithium nationallicence Substance Withdrawal Syndrome nationallicence Irish Journal of Psychological Medicine Cambridge University Press 6/1(1989-03), 23-25 0790-9667 6:1<23 1989 6 IPM https://doi.org/10.1017/S0790966700015676 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0790966700015676 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Mander A.J. University Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF NATIONALLICENCE 773 0- Irish Journal of Psychological Medicine Cambridge University Press 6/1(1989-03), 23-25 0790-9667 6:1<23 1989 6 IPM CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge