caa a22 4500 386334668 CHVBK 20180307111729.0 cr unu---uuuuu 161130e198909 xx s 000 0 eng 10.1017/S0790966700015421 doi S0790966700015421 pii (NATIONALLICENCE)cambridge-10.1017/S0790966700015421 The effect of antidepressant treatment on alpha2 adrenoceptor function in DSM 111 major depression [Elektronische Daten] [Siobhan Barry, Timothy G. Dinan] Twenty-one drug free patients fulfilling the DSM-111-R criteria for major depressive disorder were administered an alpha2 adrenoceptor challenge test. They were then treated with an antidepressant or ECT. Six weeks later, alpha2 function was again tested and found to be universally downregulated in treatment responders. Those who failed to respond to treatment (33%) had evidence of continuing alpha2 adrenoceptor activity. These results suggest central noradrenergic overactivity as a possible mechanism for depression, which runs counter to the classic catecholamine hypothesis. Copyright © Cambridge University Press 1989 Antidepressant treatment - Alpha2 adrenoceptor nationallicence Depression nationallicence Barry Siobhan Department of Psychiatry, Trinity College Medical School, St. James's Hospital, Dublin 8 aut Dinan Timothy G. Department of Psychiatry, Trinity College Medical School, St. James's Hospital, Dublin 8 aut Irish Journal of Psychological Medicine Cambridge University Press 6/2(1989-09), 109-111 0790-9667 6:2<109 1989 6 IPM https://doi.org/10.1017/S0790966700015421 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0790966700015421 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Barry Siobhan Department of Psychiatry, Trinity College Medical School, St. James's Hospital, Dublin 8 aut NATIONALLICENCE 700 1- Dinan Timothy G. Department of Psychiatry, Trinity College Medical School, St. James's Hospital, Dublin 8 aut NATIONALLICENCE 773 0- Irish Journal of Psychological Medicine Cambridge University Press 6/2(1989-09), 109-111 0790-9667 6:2<109 1989 6 IPM CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge