caa a22 4500 386345864 CHVBK 20180307111811.0 cr unu---uuuuu 161130e198911 xx s 000 0 eng 10.1017/S0022215100110904 doi S0022215100110904 pii (NATIONALLICENCE)cambridge-10.1017/S0022215100110904 James W. H. London Sex ratios in otosclerotic families [Elektronische Daten] [W. H. James] The sex ratio (proportion of males) of offspring of otosclerotics is significantly and substantially below expectation. To account for this and other features of the condition, it has been suggested elsewhere that otosclerosis is subject to autosomal dominant transmission with intrauterine selection against male heterozygotes. To test this hypothesis, a search was made for published data on the sexes of sibs of otosclerotics. These sibs do not have an unusual sex ratio, thus casting doubt on the hypothesis. Accordingly it is suggested here that both the condition and the sex ratios are causally related to levels of steroid hormones. Copyright © JLO (1984) Limited 1989 The Journal of Laryngology & Otology Cambridge University Press 103/11(1989-11), 1036-1039 0022-2151 103:11<1036 1989 103 JLO https://doi.org/10.1017/S0022215100110904 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0022215100110904 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- James W. H. London NATIONALLICENCE 773 0- The Journal of Laryngology & Otology Cambridge University Press 103/11(1989-11), 1036-1039 0022-2151 103:11<1036 1989 103 JLO CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge