caa a22 4500 386346305 CHVBK 20180307111812.0 cr unu---uuuuu 161130e198904 xx s 000 0 eng 10.1017/S0022215100108953 doi S0022215100108953 pii (NATIONALLICENCE)cambridge-10.1017/S0022215100108953 Effect of gentamicin on the carbohydrates of the vestibular end organs: An investigation by the use of FITC-lectins [Elektronische Daten] The effect of gentamicin on the glycoconjugates in the vestibular end organs is demonstrated using FITC-lectins. Five milligrams of gentamicin dissolved in 0.1 ml. saline was injected in a single dose into the middle ear of adult guinea pigs. Seven days after the injection, the fluorescent reactivity of Wheat germ agglutinin (WGA), Abrus precatorius agglutinin (APA), Concanavaline A (Con A), and Latyrus odoratus agglutinin (LOA) was decreased in the apical epithelial cell surface as well as in the gelatinous layer of the otolithic membrane of the maculae. In the cupula of the crista ampullaris, the reactivity for WGA and Con A was reduced. The otoconia, however, showed no detectable changes. This indicates that gentamicin may induce an altered carbohydrate metabolism resulting in a decrease of N-acetyl-glucosamine, mannose, galactose and glucose in the glycocalyx lining the epithelial cells as well as in the gelatinous layer of the otolithic membrane or cupula in the vestibular end organs. Copyright © JLO (1984) Limited 1989 Takumida M. Department of Otolaryngology, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden. Urquiza R. Department of Otolaryngology, University Hospital, Malaga, Spain. Bagger-Sjöbäck D. Department of Otolaryngology, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden. Wersäll J. Department of Otolaryngology, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden. The Journal of Laryngology & Otology Cambridge University Press 103/4(1989-04), 357-362 0022-2151 103:4<357 1989 103 JLO https://doi.org/10.1017/S0022215100108953 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0022215100108953 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takumida M. Department of Otolaryngology, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden NATIONALLICENCE 700 1- Urquiza R. Department of Otolaryngology, University Hospital, Malaga, Spain NATIONALLICENCE 700 1- Bagger-Sjöbäck D. Department of Otolaryngology, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden NATIONALLICENCE 700 1- Wersäll J. Department of Otolaryngology, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden NATIONALLICENCE 773 0- The Journal of Laryngology & Otology Cambridge University Press 103/4(1989-04), 357-362 0022-2151 103:4<357 1989 103 JLO CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge