caa a22 4500 386346844 CHVBK 20180307111814.0 cr unu---uuuuu 161130e198910 xx s 000 0 eng 10.1017/S0022215100110473 doi S0022215100110473 pii (NATIONALLICENCE)cambridge-10.1017/S0022215100110473 Serum antibodies against respiratory tract viruses: A prospective three-year follow-up from birth [Elektronische Daten] Acute otitis media (AOM) has been epidemiologically related to viral respiratory tract infections, and viral antigens have also been detected in middle ear secretion in some AOM episodes. Successive serum samples from children followed prospectively for three years from birth were analysed for IgG antibodies against respiratory syncytial virus (RSV), adenoviruses and influenza A virus. Values from serum antibody activity gradually decreased during the first six months of life, followed by a gradual increase. Various relationships were found to obtain between age and the increases of antibody activity against the different viruses. Thus, three quarters of those tested had manifested increased antibody activity against RSV by 18 months of age, and against adenoviruses by 30 months of age. No increase of antibody activity against influenza A was noted before 12 months of age, and then only seen in two thirds of those tested during the entire three-year observation period. With regard to age, however, the proportion of children with increased antibody activity to RSV, adenoviruses or influenza A virus did not differ between otitis-prone and non-otitis-prone children. Thus, as compared to non-otitis-prone children, development of the ability to produce antibodies against these viruses was not found to be delayed in otitis-prone children. Copyright © JLO (1984) Limited 1989 Harsten G. Department of Oto-Rhino-Laryngology, University Hospital, Lund, Sweden. Prellner K. Department of Oto-Rhino-Laryngology, University Hospital, Lund, Sweden. Löfgren B. Department of Medical Mircobiology, University Hospital, Lund, Sweden. Heldrup J. Department of Paediatrics, University Hospital, Lund, Sweden. Kalm O. Department of Oto-Rhino-Laryngology, University Hospital, Lund, Sweden. Kornfält R. Department of Paediatrics, University Hospital, Lund, Sweden. The Journal of Laryngology & Otology Cambridge University Press 103/10(1989-10), 904-908 0022-2151 103:10<904 1989 103 JLO https://doi.org/10.1017/S0022215100110473 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0022215100110473 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Harsten G. Department of Oto-Rhino-Laryngology, University Hospital, Lund, Sweden NATIONALLICENCE 700 1- Prellner K. Department of Oto-Rhino-Laryngology, University Hospital, Lund, Sweden NATIONALLICENCE 700 1- Löfgren B. Department of Medical Mircobiology, University Hospital, Lund, Sweden NATIONALLICENCE 700 1- Heldrup J. Department of Paediatrics, University Hospital, Lund, Sweden NATIONALLICENCE 700 1- Kalm O. Department of Oto-Rhino-Laryngology, University Hospital, Lund, Sweden NATIONALLICENCE 700 1- Kornfält R. Department of Paediatrics, University Hospital, Lund, Sweden NATIONALLICENCE 773 0- The Journal of Laryngology & Otology Cambridge University Press 103/10(1989-10), 904-908 0022-2151 103:10<904 1989 103 JLO CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge